Hypogammaglobulinemia with a selective delayed recovery in memory B cells and an impaired isotype expression after rituximab administration as an adjuvant to autologous stem cell transplantation for non-Hodgkin lymphoma

Nishio, Mitsufumi; Fujimoto, Katsuya; Yamamoto, Satoshi; Endo, Tomoyuki; Sakai, Toshiya; Obara, Masato; Kumano, Kohki; Minauchi, Koichiro; Yamaguchi, Keisuke; Takeda, Yukari; Sato, Norihiro; Koizumi, Kazuki; Mukai, Masaya; Koike, Takao

Hypogammaglobulinemia with a selective delayed recovery in memory B cells and an impaired isotype expression after rituximab administration as an adjuvant to autologous stem cell transplantation for non-Hodgkin lymphoma

Nishio, Mitsufumi; Fujimoto, Katsuya; Yamamoto, Satoshi et al.

European Journal Of Haematology, 2006, 77(3), 226-232

Permalink : https://hdl.handle.net/2115/28742

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アクセス権	open access
URI	https://hdl.handle.net/2115/28742
タイトル	Hypogammaglobulinemia with a selective delayed recovery in memory B cells and an impaired isotype expression after rituximab administration as an adjuvant to autologous stem cell transplantation for non-Hodgkin lymphoma
著者	Nishio, Mitsufumi ; Fujimoto, Katsuya ; Yamamoto, Satoshi ; Endo, Tomoyuki ; Sakai, Toshiya ; Obara, Masato ; Kumano, Kohki ; Minauchi, Koichiro ; Yamaguchi, Keisuke ; Takeda, Yukari ; Sato, Norihiro ; Koizumi, Kazuki ; Mukai, Masaya ; Koike, Takao
e-Rad_Researcher 10322801 著者名 Nishio, Mitsufumi
著者名 Fujimoto, Katsuya
著者名 Yamamoto, Satoshi
著者名 Endo, Tomoyuki
著者名 Sakai, Toshiya
著者名 Obara, Masato
著者名 Kumano, Kohki
著者名 Minauchi, Koichiro
著者名 Yamaguchi, Keisuke
著者名 Takeda, Yukari
著者名 Sato, Norihiro
著者名 Koizumi, Kazuki
著者名 Mukai, Masaya
e-Rad_Researcher 80146795 著者名 Koike, Takao
言語	英語
キーワード	Rituximab
	APBSCT
	hypogammaglobulinemia
	memory B-cell
	CVID
発行日	2006-09
出版者	Blackwell Publishing
収録物名	European Journal Of Haematology
巻(号)	77(3)
ページ	226-232
抄録	Objectives: Some studies have indicated patients who received rituximab as adjuvant to stem cell transplantation had an increased risk of developing severe hypogammaglobulinemia. The mechanism of this hypogammaglobulinemia is unknown, although investigators have hypothesized a further delay in the B-cell recovery as one potential etiology. The aim of this study is to clarify the mechanism(s) of this hypogammaglobulinemia. Methods: A total of 14 patients with high-risk CD20+ lymphoma underwent an autologous peripheral blood stem cell transplantation (APBSCT). After a hematological recovery, rituximab was given weekly for up to four doses as an adjuvant therapy. Results: After a median follow up of 33.5 months, we found six patients (group A) who had hypogammaglobulinemia, while the eight other patients (group B) had normal serum immunoglobulin levels. A phenotypical analysis revealed that group A patients had already achieved B-cell recovery. However, we found a severe delay in the recovery of CD27+ memory B cells, especially in the IgD /CD27+ switched populations in group A, but CD27 negative naive B-cells reverted to a normal range in both groups. Consistent with this, reverse transcriptase-polymerase chain reaction studies with peripheral blood mononuclear cells revealed that most patients in group A lacked more than two classes of isotype transcripts. Conclusions: Abnormal repertoires and impaired isotype expression are seen in patients with common variable immunodeficiency, these data suggested that rituximab after APBSCT can affect not only the B-cell quantities, but also the recovery of the B-cell repertoires.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The definitive version is available at www.blackwell-synergy.com
PISSN	0902-4441
EISSN	1600-0609
関連情報	PMID 16923109
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/j.1600-0609.2006.00693.x