LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation.

Ohbayashi, Norihiko; Ikeda, Osamu; Taira, Naohisa; Yamamoto, Yu; Muromoto, Ryuta; Sekine, Yuichi; Sugiyama, Kenji; Honjoh, Tsutomu; Matsuda, Tadashi

LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation.

Ohbayashi, Norihiko; Ikeda, Osamu; Taira, Naohisa et al.

Biological & Pharmaceutical Bulletin, 2007, 30(10), 1860-1864

Permalink : https://hdl.handle.net/2115/28780

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アクセス権	open access
URI	https://hdl.handle.net/2115/28780
タイトル	LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation.
著者	Ohbayashi, Norihiko ; Ikeda, Osamu ; Taira, Naohisa ; Yamamoto, Yu ; Muromoto, Ryuta ; Sekine, Yuichi ; Sugiyama, Kenji ; Honjoh, Tsutomu ; Matsuda, Tadashi
著者名 Ohbayashi, Norihiko
著者名 Ikeda, Osamu
著者名 Taira, Naohisa
著者名 Yamamoto, Yu
著者名 Muromoto, Ryuta
著者名 Sekine, Yuichi
著者名 Sugiyama, Kenji
著者名 Honjoh, Tsutomu
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	signal transducer and activator of transcription 3
	interleukin-6
	acetylation
	leukemia inhibitory factor
	PI3K
	Akt
発行日	2007-10
出版者	日本薬学会
出版者	The Pharmaceutical Society of Japan
収録物名	Biological & Pharmaceutical Bulletin
巻(号)	30(10)
ページ	1860-1864
抄録	Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors via specific tyrosine or serine phosphorylation, dimerization and nuclear translocation. A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation. In the present study, we created an acetyl-specific antibody against STAT3 acetylated at Lys-685, and found that leukemia inhibitory factor (LIF) or interleukin (IL)-6 induced acetylation of STAT3 at Lys-685 in 293T and Hep3B cells. Moreover, acetylation of STAT3 at Lys-685 was suppressed by PI3K inhibitor LY294002, or a dominant negative Akt. Taken together, our findings demonstrate that endogenous STAT3 is acetylated at Lys-685 by LIF or IL-6 through PI3K/Akt activation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-6158
EISSN	1347-5215
関連情報	PMID 17917251
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/bpb.30.1860