The immunomodulator FTY720 is phosphorylated and released from platelets

Anada, Yoshihiro; Igarashi, Yasuyuki; Kihara, Akio

European Journal of Pharmacology, 2007, 568(1-3), 106-111

Permalink : https://hdl.handle.net/2115/29656

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アクセス権	open access
URI	https://hdl.handle.net/2115/29656
タイトル	The immunomodulator FTY720 is phosphorylated and released from platelets
著者	Anada, Yoshihiro ; Igarashi, Yasuyuki ; Kihara, Akio
著者名 Anada, Yoshihiro
e-Rad_Researcher 70091965 著者名 Igarashi, Yasuyuki
e-Rad_Researcher 50333620 著者名 Kihara, Akio
言語	英語
キーワード	FTY720
	Sphingosine 1-phosphate
	Sphingolipid
	mmunomodulator
	Platelet
発行日	2007-07-30
出版者	Elsevier B.V.
収録物名	European Journal of Pharmacology
巻(号)	568(1-3)
ページ	106-111
抄録	The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor S1P1. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0014-2999
関連情報	PMID 17553484
関連情報	URI http://www.sciencedirect.com/science/journal/00142999
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ejphar.2007.04.053