Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma

Mega, Seiji; Miyamoto, Masaki; Li, Li et al.

Diseases of the Esophagus, 2006, 19(5), 355-359

Permalink : https://hdl.handle.net/2115/30152

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アクセス権
open access
URI
https://hdl.handle.net/2115/30152
タイトル
Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma
著者
Mega, Seiji ; Miyamoto, Masaki ; Li, Li ; Kadoya, Masatoshi ; Takahashi, Ryo ; Hase, Ryunosuke ; Kaneko, Hiroyuki ; Shichinohe, Toshiaki ; Kawarada, You ; Itoh, Tomoo ; Morikawa, Toshiaki ; Kondo, Satoshi
著者名
Mega, Seiji
著者名
Miyamoto, Masaki
著者名
Li, Li
著者名
Kadoya, Masatoshi
著者名
Takahashi, Ryo
著者名
Hase, Ryunosuke
著者名
Kaneko, Hiroyuki
e-Rad_Researcher
70374353
著者名
Shichinohe, Toshiaki
著者名
Kawarada, You
著者名
Itoh, Tomoo
著者名
Morikawa, Toshiaki
e-Rad_Researcher
30215454
著者名
Kondo, Satoshi
言語
英語
キーワード
survivin
esophageal squamous cell carcinoma
immunohistochemistry
carcinogenesis
prognosis
発行日
2006-10
出版者
Blackwell Publishing
収録物名
Diseases of the Esophagus
巻(号)
19(5)
ページ
355-359
抄録
Despite advances in the treatment of esophageal carcinoma, the prognosis for this disease remains poor. Therefore, it is important to obtain a better understanding of the molecular basis of esophageal carcinogenesis. The purpose of this study was to clarify the roles of survivin in esophageal squamous cell carcinoma (ESCC). One hundred 22 ESCC surgical specimens resected from 1989 to 1999 were examined. Survivin expression was assessed by immunohistochemistry. Tumor cells were considered survivin-positive if the immunoreactivity was confined to the nucleus, and a scoring method was applied. Survivin-positive immunostaining was detected in 68 patients (56%). There was a significant association between survivin expression and pN (P = 0.0472). Moreover, the overall survival rate was worse in patients with survivin-positive tumors than in patients with survivin-negative tumors (P = 0.0189). The overexpression of survivin was associated with the overall survival rate and poor prognosis in patients with ESCC. Survivin may be targeted during cancer therapy because of its selective expression in malignant tissue.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The definitive version is available at www.blackwell-synergy.com
PISSN
1120-8694
EISSN
1442-2050
関連情報
PMID
16984532
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1111/j.1442-2050.2006.00604.x