Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan

Endo, Rika; Ishiguro, Nobuhisa; Kikuta, Hideaki; Teramoto, Shinobu; Shirkoohi, Reza; Ma, Xiaoming; Ebihara, Takashi; Ishiko, Hiroaki; Ariga, Tadashi

Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan

Endo, Rika; Ishiguro, Nobuhisa; Kikuta, Hideaki et al.

Journal of Clinical Microbiology, 2007, 45(10), 3218-3223

Permalink : https://hdl.handle.net/2115/30195

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/30195
タイトル	Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan
著者	Endo, Rika ; Ishiguro, Nobuhisa ; Kikuta, Hideaki ; Teramoto, Shinobu ; Shirkoohi, Reza ; Ma, Xiaoming ; Ebihara, Takashi ; Ishiko, Hiroaki ; Ariga, Tadashi
著者名 Endo, Rika
e-Rad_Researcher 40168216 著者名 Ishiguro, Nobuhisa
著者名 Kikuta, Hideaki
著者名 Teramoto, Shinobu
著者名 Shirkoohi, Reza
著者名 Ma, Xiaoming
著者名 Ebihara, Takashi
著者名 Ishiko, Hiroaki
著者名 Ariga, Tadashi
言語	英語
発行日	2007-10
出版者	American Society for Microbiology
収録物名	Journal of Clinical Microbiology
巻(号)	45(10)
ページ	3218-3223
抄録	A new human virus, provisionally named human bocavirus (HBoV), was discovered by Swedish researchers in 2005. A new immunofluorescence assay using Trichoplusia ni insect cells infected with a recombinant baculovirus expressing the VP1 protein of HBoV was developed, and the levels of immunoglobulin G antibody to the VP1 protein of HBoV in serum samples were measured. The overall seroprevalence rate of antibodies against the VP1 protein of HBoV in a Japanese population aged from 0 months to 41 years was 71.1% (145 of 204). The seropositive rate was lowest in the age group of 6 to 8 months and gradually increased with age. All of the children had been exposed to HBoV by the age of 6 years. A rise in titers of antibody against the VP1 protein of HBoV during the convalescent phase was observed for four patients with lower respiratory tract infections, and HBoV DNA was detected in nasopharyngeal swab and serum samples from all four patients. These results suggest that HBoV is a ubiquitous virus acquired early in life and that HBoV might play a role in the course of lower respiratory tract infections.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright © American Society for Microbiology
PISSN	0095-1137
関連情報	PMID 17699639
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1128/JCM.02140-06