Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE−/− mice

Zhao, Yan; Kuge, Yuji; Zhao, Songji; Morita, Koichi; Inubushi, Masayuki; Strauss, H. William; Blankenberg, Francis G.; Tamaki, Nagara

Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE−/− mice

Zhao, Yan; Kuge, Yuji; Zhao, Songji et al.

European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34(11), 1747-1755

Permalink : https://hdl.handle.net/2115/30199

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アクセス権	open access
URI	https://hdl.handle.net/2115/30199
タイトル	Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE−/− mice
その他のタイトル	Comparison of 99mTc-annexin A5 with 18F-FDG for detecting atherosclerosis in ApoE-/- mice
著者	Zhao, Yan ; Kuge, Yuji ; Zhao, Songji ; Morita, Koichi ; Inubushi, Masayuki ; Strauss, H. William ; Blankenberg, Francis G. ; Tamaki, Nagara
著者名 Zhao, Yan
著者名 Kuge, Yuji
著者名 Zhao, Songji
著者名 Morita, Koichi
著者名 Inubushi, Masayuki
著者名 Strauss, H. William
著者名 Blankenberg, Francis G.
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
言語	英語
キーワード	Atherosclerosis
	Apoptosis
	99mTc-annexin A5
	18F-FDG
	Apolipoprotein E-knockout mouse
発行日	2007-11
出版者	Springer Berlin / Heidelberg
収録物名	European Journal of Nuclear Medicine and Molecular Imaging
巻(号)	34(11)
ページ	1747-1755
抄録	Purpose: 99mTc-annexin A5, a marker of ongoing apoptosis, and 18F-FDG, a marker of the increased metabolism of inflammatory cells, are supposed to be useful in the detection of metabolically active atheroma. This study reports a comparison of the intralesional distribution of these tracers in relation to lesion development in ApoE−/− mice. Methods: Male ApoE−/− mice (n = 12–14/group) were maintained on a Western-type diet after the age of 5 weeks. At 25 weeks, 99mTc-annexin A5 or 18F-FDG was injected and the aortas were harvested for autoradiography (ARG) and Oil Red O staining. Regional radioactivity accumulation was compared in relation to the Oil Red O staining score (ranging from 0 to 3, a semiquantitative parameter for evaluating lesion development). Results: Both 99mTc-annexin A5 and 18F-FDG showed preferential uptake into atherosclerotic lesions, with higher uptake levels for 18F-FDG (mean, 56.07 %ID×kg/m2) than for 99mTc-annexin A5 (mean, 10.38 %ID×kg/m2). The regional uptake levels of each tracer correlated with the Oil Red O staining score (r = 0.65, p < 0.05 for 99mTc-annexin A5; r = 0.56, p < 0.05 for 18F-FDG). The uptake ratios of advanced lesions (score >0.5) to early lesions (score <0.5) were significantly higher for 99mTc-annexin A5 than for 18F-FDG (f = 4.73, p = 0.03). Conclusion: Both 99mTc-annexin A5 and 18F-FDG accumulate in atherosclerotic lesions and correlate with the severity of each lesion. The higher absolute uptake levels of 18F-FDG may be advantageous for lesion detection, whereas the preferential uptake of 99mTc-annexin A5 in advanced lesions may be a useful indicator of late-stage lesions or vulnerable plaque transformation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0340-6997
EISSN	1619-7089
関連情報	PMID 17437104
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00259-007-0433-2