Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients

Toubai, Tomomi; Tanaka, Junji; Ota, Shuichi; Fukuhara, Takashi; Hashino, Satoshi; Kondo, Takeshi; Shono, Yusuke; Morioka, Masanobu; Kawamura, Tsugumichi; Masauzi, Nobuo; Kakinoki, Yasutaka; Kobayashi, Hajime; Kunieda, Yasuyuki; Kasai, Masaharu; Kurosawa, Mitsutoshi; Asaka, Masahiro; Imamura, Masahiro

Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients

Toubai, Tomomi; Tanaka, Junji; Ota, Shuichi et al.

European Journal Of Haematology, 2006, 77(5), 403-409

Permalink : https://hdl.handle.net/2115/30221

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アクセス権	open access
URI	https://hdl.handle.net/2115/30221
タイトル	Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients
著者	Toubai, Tomomi ; Tanaka, Junji ; Ota, Shuichi ; Fukuhara, Takashi ; Hashino, Satoshi ; Kondo, Takeshi ; Shono, Yusuke ; Morioka, Masanobu ; Kawamura, Tsugumichi ; Masauzi, Nobuo ; Kakinoki, Yasutaka ; Kobayashi, Hajime ; Kunieda, Yasuyuki ; Kasai, Masaharu ; Kurosawa, Mitsutoshi ; Asaka, Masahiro ; Imamura, Masahiro
著者名 Toubai, Tomomi
e-Rad_Researcher 50250452 著者名 Tanaka, Junji
著者名 Ota, Shuichi
著者名 Fukuhara, Takashi
e-Rad_Researcher 60271665 著者名 Hashino, Satoshi
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
著者名 Shono, Yusuke
著者名 Morioka, Masanobu
著者名 Kawamura, Tsugumichi
著者名 Masauzi, Nobuo
著者名 Kakinoki, Yasutaka
著者名 Kobayashi, Hajime
著者名 Kunieda, Yasuyuki
著者名 Kasai, Masaharu
著者名 Kurosawa, Mitsutoshi
著者名 Asaka, Masahiro
著者名 Imamura, Masahiro
言語	英語
キーワード	IL-12
	IL-12 p40
	IL-12 p35
	non-Hodgkin’s lymphoma
	G-CSF
発行日	2006-11
出版者	Blackwell Publishing
収録物名	European Journal Of Haematology
巻(号)	77(5)
ページ	403-409
抄録	Interleukin (IL)-12 is a 70-kDa cytokine comprised of two disulfide-linked proteins (p35 and p40) and is essential for the initiation of effective immune response. Granulocyte-colony stimulating factor (G-CSF) affects the balance in the production of anti-inflammatory cytokines. We investigated the serum IL-12 p40 and IL-12 Mix (p40 and p70) production in 28 patients with B-cell lineage non-Hodgkin's lymphoma (NHL) treated with chemotherapy (e.g., CHOP regimen) with or without G-CSF administration and eight healthy volunteers. We found that serum levels of IL-12 p40 (191.2 ± 150.0 pg/mL) and IL-12 Mix (277.4 ± 274.5 pg/mL) in the patients before chemotherapy were higher than those in the healthy volunteers (IL-12 p40: 76.4 ± 25.3 pg/mL, IL-12 Mix: 48.5 ± 33.4 pg/mL) (P = 0.04 and 0.02, respectively). Next, we examined the serum IL-12 p40 and IL-12 Mix levels in nine patients receiving chemotherapy with administration of G-CSF (CG group, n = 9) and without G-CSF (C group, n = 9). Serum IL-12 p40 and IL-12 Mix levels were decreased on 10 d after chemotherapy in both groups, and those in CG groups were significantly lower than those in C group. These results indicated that administration of G-CSF decreased serum IL-12 p40 and IL-12 Mix levels. Overall survival (OS) at 24 months was not significantly different in the two groups (58.3% in group C vs. 80.0% in group CG, P = 0.67). However, the survival rate of patients at clinical stages III and IV in CG group (n = 6, 66.0%) was significantly better than that of patients in C group (n = 4, 25.0%) (P = 0.02). Long-term administration of G-CSF appears to influence the survival rate by reducing immunosuppressive IL-12 p40 production.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The definitive version is available at www.blackwell-synergy.com
PISSN	0902-4441
EISSN	1600-0609
関連情報	PMID 16930137
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/j.1600-0609.2006.00746.x