Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells

Onoé, Kazunori; Yanagawa, Yoshiki; Minami, Keita et al.

Immunologic Research, 2007, 38(1-3), 319-332

Permalink : https://hdl.handle.net/2115/30286

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/30286
タイトル
Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells
著者
Onoé, Kazunori ; Yanagawa, Yoshiki ; Minami, Keita ; Iijima, Norifumi ; Iwabuchi, Kazuya
著者名
Onoé, Kazunori
著者名
Yanagawa, Yoshiki
著者名
Minami, Keita
著者名
Iijima, Norifumi
著者名
Iwabuchi, Kazuya
言語
英語
キーワード
Th1/Th2
Dendritic cells
NKT cells
Feedback regulation
CD40
Anti-cancer
IFN-γ
発行日
2007-07
出版者
Humana Press Inc.
収録物名
Immunologic Research
巻(号)
38(1-3)
ページ
319-332
抄録
If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by α-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The original publication is available at www.springerlink.com
PISSN
0257-277X
EISSN
0257-277X
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s12026-007-0011-5