Testicular toxicity of profenofos in matured male rats

Moustafa, Gihan Gamal; Ibrahim, Zein Shaban; Hashimoto, Yoshiharu et al.

Archives of Toxicology, 2007, 81(12), 875-881

Permalink : https://hdl.handle.net/2115/32319

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アクセス権
open access
URI
https://hdl.handle.net/2115/32319
タイトル
Testicular toxicity of profenofos in matured male rats
著者
Moustafa, Gihan Gamal ; Ibrahim, Zein Shaban ; Hashimoto, Yoshiharu ; Alkelch, M. Alkelch ; Sakamoto, Kentaro Q. ; Ishizuka, Mayumi ; Fujita, Shoichi
著者名
Moustafa, Gihan Gamal
著者名
Ibrahim, Zein Shaban
e-Rad_Researcher
20091481
著者名
Hashimoto, Yoshiharu
著者名
Alkelch, M. Alkelch
e-Rad_Researcher
80374627
著者名
Sakamoto, Kentaro Q.
e-Rad_Researcher
50332474
著者名
Ishizuka, Mayumi
e-Rad_Researcher
10143314
著者名
Fujita, Shoichi
言語
英語
キーワード
profenofos
cytochrome P450
testosterone
testis
発行日
2007-12
出版者
Springer
収録物名
Archives of Toxicology
巻(号)
81(12)
ページ
875-881
抄録
To investigate the effect of the phosphorothoate insecticide profenofos on male specific gene expression on rat testis, 16-week-old Wistar rats were orally administered at dose of 17.8 mg/kg twice weekly for 65 days. Gene expression in the testes was monitored by DNA microarray analysis and real-time RT-PCR, which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased. Besides the testes were histopathologicaly examined, which revealed testicular destruction and degeneration represented by a layer of columnar epithelium, oedematous changes surrounding the seminiferous tubules besides vacuolated spermatogonial cells and more elongated Leydig cells. These data suggest that profenofos considered as one of the male reproductive toxicants. Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The original publication is available at www.springerlink.com
PISSN
0340-5761
EISSN
1432-0738
関連情報
PMID
17569032
URI
http://www.springerlink.com
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s00204-007-0217-2