Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.

Hachiro, Takeru; Kawahara, Koichi; Sato, Rie; Yamauchi, Yoshiko; Matsuyama, Daisuke

Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.

Hachiro, Takeru; Kawahara, Koichi; Sato, Rie et al.

Biosystems, 2007, 90(3), 707-715

Permalink : https://hdl.handle.net/2115/32320

このアイテムのアクセス数:1,355件（2026-10-13 20:11 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
BS90-3	pdf	881 KB	1,800

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/32320
タイトル	Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.
著者	Hachiro, Takeru ; Kawahara, Koichi ; Sato, Rie ; Yamauchi, Yoshiko ; Matsuyama, Daisuke
著者名 Hachiro, Takeru
e-Rad_Researcher 20125397 著者名 Kawahara, Koichi
著者名 Sato, Rie
著者名 Yamauchi, Yoshiko
著者名 Matsuyama, Daisuke
言語	英語
キーワード	fluctuation of contraction rhythm
	cardiac myocytes
	cardiac fibroblasts
	gap junctions
	development
発行日	2007-11
出版者	Elsevier
収録物名	Biosystems
巻(号)	90(3)
ページ	707-715
抄録	The heart functions as a syncytium of cardiac myocytes and surrounding supportive non-myocytes such as fibroblasts. There is a possibility that a variety of non-myocyte-derived factors affect the maturation of cardiac myocytes in the development of the heart. Cultured neonatal cardiac myocytes contract spontaneously and cyclically. The fluctuation of beating rhythm varies depending on the strength of coupling through gap junctions among cardiac myocytes, indicating that the development of intercellular communication via gap junctions is crucial to the stability of contraction rhythm in cardiac myocytes. In this study, we aimed at elucidating whether and how cardiac fibroblasts affect the development of cardiac myocytes from the point of view of the changes in the fluctuation of the contraction rhythm of cardiac myocytes in cardiac myocyte-fibroblast co-cultures. The present study suggested that cardiac fibroblasts co-cultured with cardiac myocytes enhanced the intercellular communication among myocytes via gap junctions, thereby stabilizing the spontaneous contraction rhythm of cultured cardiac myocytes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0303-2647
関連情報	PMID 17418939
関連情報	URI http://www.sciencedirect.com/science/journal/03032647
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.biosystems.2007.02.009