Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA

Maruyama, Satoru; Miyajima, Naoto; Bohgaki, Miyuki; Tsukiyama, Tadasuke; Shigemura, Masahiko; Nonomura, Katsuya; Hatakeyama, Shigetsugu

Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA

Maruyama, Satoru; Miyajima, Naoto; Bohgaki, Miyuki et al.

Molecular and Cellular Biochemistry, 2008, 307(1-2), 73-82

Permalink : https://hdl.handle.net/2115/32324

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アクセス権	open access
URI	https://hdl.handle.net/2115/32324
タイトル	Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA
著者	Maruyama, Satoru ; Miyajima, Naoto ; Bohgaki, Miyuki ; Tsukiyama, Tadasuke ; Shigemura, Masahiko ; Nonomura, Katsuya ; Hatakeyama, Shigetsugu
著者名 Maruyama, Satoru
著者名 Miyajima, Naoto
著者名 Bohgaki, Miyuki
著者名 Tsukiyama, Tadasuke
著者名 Shigemura, Masahiko
著者名 Nonomura, Katsuya
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
キーワード	PIRH2
	ε-COP
	ubiquitin
	androgen receptor
	PSA
発行日	2008-01
出版者	Springer
収録物名	Molecular and Cellular Biochemistry
巻(号)	307(1-2)
ページ	73-82
抄録	Ubiquitylation appears to be involved in the membrane trafficking system including endocytosis, exocytosis, and ER-to-Golgi transport. We found that PIRH2, which was identified as an interacting protein for androgen receptor or p53, interacts with and ubiquitylates the ε-subunit of coatmer complex, ε-COP. PIRH2 promotes the ubiquitylation of ε-COP in vitro and in vivo and consequently promotes the degradation of ε-COP. The interaction between PIRH2 and ε-COP is affected by the presence of androgen, and PIRH2 in the presence of androgen promotes ubiquitylation of ε-COP in vivo. Furthermore, overexpression of the wild type of PIRH2 in prostate cancer cells causes downregulation of the secretion of prostate-specific antigen (PSA), a secretory protein in prostate epithelial cells and one of diagnostic markers for prostate cancer. Our results indicate that PIRH2 functions as a regulator for COP I complex.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0300-8177
EISSN	1573-4919
関連情報	PMID 17721809
関連情報	URI http://www.springerlink.com
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11010-007-9586-3