A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes

Kaneko, Masayuki; Yasui, Saori; Niinuma, Yoshifumi et al.

FEBS Letters, 2007, 581(28), 5355-5360

Permalink : https://hdl.handle.net/2115/32746

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アクセス権
open access
URI
https://hdl.handle.net/2115/32746
タイトル
A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes
著者
Kaneko, Masayuki ; Yasui, Saori ; Niinuma, Yoshifumi ; Arai, Kiho ; Omura, Tomohiro ; Okuma, Yasunobu ; Nomura, Yasuyuki
著者名
Kaneko, Masayuki
著者名
Yasui, Saori
著者名
Niinuma, Yoshifumi
著者名
Arai, Kiho
著者名
Omura, Tomohiro
著者名
Okuma, Yasunobu
著者名
Nomura, Yasuyuki
言語
英語
キーワード
HRD1
SEL1
ER stress
ATF6
XBP1
ERAD
発行日
2007-11-27
出版者
Elsevier Science
収録物名
FEBS Letters
巻(号)
581(28)
ページ
5355-5360
抄録
Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively. These results suggest that the ER stress-induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0014-5793
関連情報
PMID
17967421
URI
http://www.sciencedirect.com/science/journal/00145793
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.febslet.2007.10.033