Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats

Itagaki, Shirou; Chiba, Makoto; Kobayashi, Masaki et al.

Biochimica et Biophysica Acta (BBA). Biomembranes, 2008, 1778(1), 270-275

Permalink : https://hdl.handle.net/2115/33066

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アクセス権
open access
URI
https://hdl.handle.net/2115/33066
タイトル
Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats
著者
Itagaki, Shirou ; Chiba, Makoto ; Kobayashi, Masaki ; Sugawara, Mitsuru ; Kobayashi, Michlya ; Hirano, Takeshi ; Iseki, Ken
著者名
Itagaki, Shirou
著者名
Chiba, Makoto
e-Rad_Researcher
70431319
著者名
Kobayashi, Masaki
著者名
Sugawara, Mitsuru
著者名
Kobayashi, Michlya
著者名
Hirano, Takeshi
e-Rad_Researcher
40203062
著者名
Iseki, Ken
言語
英語
キーワード
LEC rats
urinary excretion
transporter
organic anion
urate
発行日
2008-01
出版者
Elsevier
収録物名
Biochimica et Biophysica Acta (BBA). Biomembranes
巻(号)
1778(1)
ページ
270-275
抄録
It has been reported that the transport function for organic anions on the kidney is maintained in multidrug resistance-associated protein 2 (Mrp2)-deficient rats. Different from Mrp2-deficient rats, Long-Evans Cinnamon (LEC) rats have impaired urinary excretion of Mrp2-substrate, phenolsulfonphthalein (PSP). PSP is transported by the potential-sensitive urate transport system in rat brush-border membranes. We analyzed the function of PSP transport system in LEC rats. Unlike Long-Evans Agouti (LEA) rats, the initial uptake of PSP and urate into the renal brush-border membrane vesicles of LEC rats were not significantly enhanced in the presence of positive intravesicular potential, suggesting that the potential-sensitive urate transport system is impaired in LEC rats. LEC rats should be useful for elucidating the potential-sensitive urate transport system in rats at the molecular level.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0005-2736
NCID
AA00564657
関連情報
PMID
17976528
URI
http://www.sciencedirect.com/science/journal/00052736
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbamem.2007.09.025