The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction

Ohbayashi, Norihiko; Kawakami, Shiho; Muromoto, Ryuta et al.

Biochemical and Biophysical Research Communications, 2008, 371(4), 823-828

Permalink : https://hdl.handle.net/2115/33894

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アクセス権
open access
URI
https://hdl.handle.net/2115/33894
タイトル
The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
その他のタイトル
IL-6 desumoylates PML via SENP1
著者
Ohbayashi, Norihiko ; Kawakami, Shiho ; Muromoto, Ryuta ; Togi, Sumihito ; Ikeda, Osamu ; Kamitani, Shinya ; Sekine, Yuichi ; Honjoh, Tsutomu ; Matsuda, Tadashi
著者名
Ohbayashi, Norihiko
著者名
Kawakami, Shiho
著者名
Muromoto, Ryuta
著者名
Togi, Sumihito
著者名
Ikeda, Osamu
著者名
Kamitani, Shinya
著者名
Sekine, Yuichi
著者名
Honjoh, Tsutomu
e-Rad_Researcher
20212219
著者名
Matsuda, Tadashi
言語
英語
キーワード
IL-6
LIF
SENP1
SUMO
STAT3
PML
transcriptional regulation
発行日
2008-07-11
出版者
Academic Press
収録物名
Biochemical and Biophysical Research Communications
巻(号)
371(4)
ページ
823-828
抄録
Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0006-291X
EISSN
1090-2104
NCID
AA00564395
関連情報
PMID
18474224
URI
http://www.sciencedirect.com/science/journal/0006291X
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbrc.2008.04.179