Mechanism of apoptosis induced by copper in PC12 cells

Kawakami, Masaki; Inagawa, Rieko; Hosokawa, Toshiyuki et al.

Food and Chemical Toxicology, 2008, 46(6), 2157-2164

Permalink : https://hdl.handle.net/2115/34121

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/34121
タイトル
Mechanism of apoptosis induced by copper in PC12 cells
著者
Kawakami, Masaki ; Inagawa, Rieko ; Hosokawa, Toshiyuki ; Saito, Takeshi ; Kurasaki, Masaaki
著者名
Kawakami, Masaki
著者名
Inagawa, Rieko
著者名
Hosokawa, Toshiyuki
著者名
Saito, Takeshi
著者名
Kurasaki, Masaaki
言語
英語
キーワード
apoptosis
copper
PC12 cell
caspase
cytochrome c
Bcl-2 family
発行日
2008-06
出版者
Pergamon-Elsevier Science
収録物名
Food and Chemical Toxicology
巻(号)
46(6)
ページ
2157-2164
抄録
Copper, an essential trace element, induces apoptosis in mammalian cells. However, the precise mechanism of copper-induced apoptosis is still unclear. In this study, to determine the apoptotic pathway initiated by copper treatment, apoptotic factors such as Bax, Bad and Bcl-2, and the caspase family in PC 12 cells treated with copper were measured by Western blot and RT-PCR analyses. The expression of Bax, Bad, cytochrome c and caspases 3 and 9 were increased by copper treatment. From these results, two pathways for copper-induced apoptosis were suggested. At first, an increase of Bax induces the release of cytochrome c from the mitochondria into the cytoplasm owing to binding to apoptotic activating caspase 9 leading to the activation of caspases 3. In the other pathway an increase of Bax and reactive oxygen species activates the release of AIF from the mitochondria. The AIF induces apoptosis via a caspase-independent pathway.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0278-6915
関連情報
PMID
18381230
URI
http://www.sciencedirect.com/science/journal/02786915
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.fct.2008.02.014