Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.

Horie, Yukihiro; Takemoto, Yuko; Miyazaki, Akiko; Namba, Kenichi; Kase, Satoru; Yoshida, Kazuhiko; Ota, Masao; Hasumi, Yukiko; Inoko, Hidetoshi; Mizuki, Nobuhisa; Ohno, Shigeaki

Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.

Horie, Yukihiro; Takemoto, Yuko; Miyazaki, Akiko et al.

Molecular Vision, 2006, 12, 1601-1605

Permalink : https://hdl.handle.net/2115/34400

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アクセス権	open access
URI	https://hdl.handle.net/2115/34400
タイトル	Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.
著者	Horie, Yukihiro ; Takemoto, Yuko ; Miyazaki, Akiko ; Namba, Kenichi ; Kase, Satoru ; Yoshida, Kazuhiko ; Ota, Masao ; Hasumi, Yukiko ; Inoko, Hidetoshi ; Mizuki, Nobuhisa ; Ohno, Shigeaki
著者名 Horie, Yukihiro
e-Rad_Researcher 20443939 著者名 Takemoto, Yuko
著者名 Miyazaki, Akiko
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
e-Rad_Researcher 60374394 著者名 Kase, Satoru
e-Rad_Researcher 90281807 著者名 Yoshida, Kazuhiko
著者名 Ota, Masao
著者名 Hasumi, Yukiko
著者名 Inoko, Hidetoshi
著者名 Mizuki, Nobuhisa
e-Rad_Researcher 50002382 著者名 Ohno, Shigeaki
言語	英語
発行日	2006-12-20
出版者	Molecular Vision
収録物名	Molecular Vision
巻(号)	12
ページ	1601-1605
抄録	PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT)). METHODS: 87 VKH patients and 122 healthy controls were genotyped using seven microsatellite markers on the candidate loci. We analyzed microsatellite (MS) polymorphisms at regions within tyrosinase gene family loci. In addition, the haplotype frequencies were also estimated and statistical analysis was performed. HLA-DRB1 genotyping was performed by the PCR-restriction fragment length polymorphism (RFLP) method. RESULTS: No significant evidence for an association was found. HLA-DRB1*0405 showed a highly significant association with VKH disease compared with the healthy controls (Pc=0.000000079), as expected. CONCLUSIONS: We concluded that there is no genetic susceptibility or increased risk attributed to the tyrosinase gene family. Our results suggest the need for further genetic study and encourage a search for novel genetic loci and predisposing genes in order to elucidate the genetic mechanisms underlying VKH disease.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright (c) 2006 Molecular Vision
PISSN	1090-0535
EISSN	1090-0535
関連情報	PMID 17200659
関連情報	URI http://www.molvis.org/molvis/v12/a183/