Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.

Horie, Yukihiro; Kitaichi, Nobuyoshi; Takemoto, Yuko; Namba, Kenichi; Yoshida, Kazuhiko; Hirose, Shigeto; Hasumi, Yukiko; Ota, Masao; Inoko, Hidetoshi; Mizuki, Nobuhisa; Ohno, Shigeaki

Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.

Horie, Yukihiro; Kitaichi, Nobuyoshi; Takemoto, Yuko et al.

Molecular Vision, 2007, 13, 2334-2338

Permalink : https://hdl.handle.net/2115/34401

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アクセス権	open access
URI	https://hdl.handle.net/2115/34401
タイトル	Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.
著者	Horie, Yukihiro ; Kitaichi, Nobuyoshi ; Takemoto, Yuko ; Namba, Kenichi ; Yoshida, Kazuhiko ; Hirose, Shigeto ; Hasumi, Yukiko ; Ota, Masao ; Inoko, Hidetoshi ; Mizuki, Nobuhisa ; Ohno, Shigeaki
著者名 Horie, Yukihiro
e-Rad_Researcher 40431366 著者名 Kitaichi, Nobuyoshi
e-Rad_Researcher 20443939 著者名 Takemoto, Yuko
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
e-Rad_Researcher 90281807 著者名 Yoshida, Kazuhiko
著者名 Hirose, Shigeto
著者名 Hasumi, Yukiko
著者名 Ota, Masao
著者名 Inoko, Hidetoshi
著者名 Mizuki, Nobuhisa
e-Rad_Researcher 50002382 著者名 Ohno, Shigeaki
言語	英語
発行日	2007-12-21
出版者	Molecular Vision
収録物名	Molecular Vision
巻(号)	13
ページ	2334-2338
抄録	PURPOSE: Interferon-gamma (IFN-gamma) is a key cytokine in inflammatory disorders. Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with Vogt-Koyanagi-Harada (VKH) disease. The aim of this study was to determine the IFN-gamma gene polymorphisms in VKH disease. METHODS: The study involved 136 VKH patients and 176 healthy controls, who were genotyped for functional single nucleotide polymorphism (SNP; rs2430561; A/T) and functional microsatellite (CA) repeats (rs3138557) in the first intron of the IFN-gamma gene. Moreover, clinical manifestations of the patients were also analyzed. RESULTS: Diffuse choroiditis/staining of fluorescein angiography was seen in all VKH patients in this study. Sunset glow fundus and nummular chorioretinal depigmented scars were observed in 83.9%, and 36.1% of the patients, respectively. Neurological and auditory disorders were observed in 90.1% of the patients: meningismus (79.8%), tinnitus (53.0%), and cerebrospinal fluid pleocytosis (70.0%). Dermatologic manifestations were observed in 22.9% of the patients, manifesting as alopecia (6.9%), poliosis (17.6%), and vitiligo (13.0%). In addition, 22.1% of the patients were classified as having complete VKH disease, while 65.4% as having incomplete VKH disease, and 12.5% as having probable VKH disease. There were no significant differences in the allele and genotype frequencies between VKH patients and healthy controls. In addition, we found no association between each clinical manifestation and SNP (re2430561) in the healthy control subject. A strong linkage disequilibrium (LD) was found in the functional SNP T allele and functional microsatellite 12 (CA) repeats (D'=0.96-0.99). CONCLUSIONS: The functional SNP T allele and microsatellite 12 (CA) repeats were found to have a strong LD, although a genetic susceptibility for the IFN-gamma gene could not be demonstrated among the Japanese VKH patients.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright (c) 2007 Molecular Vision
PISSN	1090-0535
EISSN	1090-0535
関連情報	PMID 18199975
関連情報	URI http://www.molvis.org/molvis/v13/a264/