Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice

Ikeda, Osamu; Sekine, Yuichi; Muromoto, Ryuta; Ohbayashi, Norihiko; Yoshimura, Akihiko; Matsuda, Tadashi

Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice

Ikeda, Osamu; Sekine, Yuichi; Muromoto, Ryuta et al.

Biological & Pharmaceutical Bulletin, 2008, 31(9), 1790-1793

Permalink : https://hdl.handle.net/2115/34686

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アクセス権	open access
URI	https://hdl.handle.net/2115/34686
タイトル	Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice
著者	Ikeda, Osamu ; Sekine, Yuichi ; Muromoto, Ryuta ; Ohbayashi, Norihiko ; Yoshimura, Akihiko ; Matsuda, Tadashi
著者名 Ikeda, Osamu
著者名 Sekine, Yuichi
著者名 Muromoto, Ryuta
著者名 Ohbayashi, Norihiko
著者名 Yoshimura, Akihiko
著者名 Matsuda, Tadashi
言語	英語
キーワード	signal-transducing adaptor protein-2
	M-CSF
	c-Fms
	macrophage
	wound-healing
発行日	2008-09-01
出版者	The Pharmaceutical Society of Japan
収録物名	Biological & Pharmaceutical Bulletin
巻(号)	31(9)
ページ	1790-1793
抄録	Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7. Overexpression of STAP-2 in Raw264.7 cells markedly suppressed M-CSF-induced activation of extracellular signal regulated kinase and Akt. In addition, Raw264.7 overexpressing STAP-2 affected cell migration in wound-healing process. These results suggest that STAP-2 deficiency influences endogenous c-Fms/M-CSF receptor signaling. Here we show that loss of STAP-2 expression in knockout mouse macrophages results in marked enhancement of the c-Fms/M-CSF receptor signaling and wound-healing process. We therefore propose that STAP-2 acts as an endogenous regulator in normal macrophages functions.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-6158
EISSN	1347-5215
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/bpb.31.1790