Physical and functional interactions between STAT3 and KAP1

Tsuruma, Rieko; Ohbayashi, Norihiko; Kamitani, Shinya; Ikeda, Osamu; Sato, Noriko; Muromoto, Ryuta; Sekine, Yuichi; Oritani, Kenji; Matsuda, Tadashi

Physical and functional interactions between STAT3 and KAP1

Tsuruma, Rieko; Ohbayashi, Norihiko; Kamitani, Shinya et al.

Oncogene, 2008, 27(21), 3054-3059

Permalink : https://hdl.handle.net/2115/34959

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アクセス権	open access
URI	https://hdl.handle.net/2115/34959
タイトル	Physical and functional interactions between STAT3 and KAP1
その他のタイトル	Interactions between STAT3 and KAP1
著者	Tsuruma, Rieko ; Ohbayashi, Norihiko ; Kamitani, Shinya ; Ikeda, Osamu ; Sato, Noriko ; Muromoto, Ryuta ; Sekine, Yuichi ; Oritani, Kenji ; Matsuda, Tadashi
著者名 Tsuruma, Rieko
著者名 Ohbayashi, Norihiko
著者名 Kamitani, Shinya
著者名 Ikeda, Osamu
著者名 Sato, Noriko
著者名 Muromoto, Ryuta
著者名 Sekine, Yuichi
著者名 Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	IL-6
	STAT3
	KAP1
	transcriptional regulation
	phosphorylation
発行日	2008-05-08
出版者	Nature Publishing Group
収録物名	Oncogene
巻(号)	27(21)
ページ	3054-3059
抄録	Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. For example, STAT3 has been reported to be constitutively activated in numerous cancer cells. To clarify the molecular mechanisms underlying the STAT activation, we performed yeast twohybrid screening and identified KAP1/TIF1β as a novel STAT-binding partner. KAP1 is a universal corepressor protein for the KRAB zinc finger protein superfamily of transcriptional repressors. We found endogenous KAP1 associated with endogenous STAT3 in vivo. Importantly, small-interfering RNA-mediated reduction of KAP1 expression enhanced IL-6-induced STAT3-dependent transcription and gene expression. Furthermore, reduction of KAP1 expression resulted in the marked nuclear accumulation of STAT3 phosphorylated on Ser727 in the nucleus, a modification that regulates its transcriptional activation. These results indicate that KAP1 may serve as a transcriptional regulator of the IL-6/STAT3 signaling pathway.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0950-9232
EISSN	0950-9232
NCID	AA10687380
関連情報	PMID 18037959
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/sj.onc.1210952