HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A

Togi, Sumihito; Kamitani, Shinya; Kawakami, Shiho; Ikeda, Osamu; Muromoto, Ryuta; Nanbo, Asuka; Matsuda, Tadashi

HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A

Togi, Sumihito; Kamitani, Shinya; Kawakami, Shiho et al.

Biochemical and Biophysical Research Communications, 2009, 379(2), 616-620

Permalink : https://hdl.handle.net/2115/35328

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アクセス権	open access
URI	https://hdl.handle.net/2115/35328
タイトル	HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A
その他のタイトル	Interactions among STAT3, HDAC3 and PP2A
著者	Togi, Sumihito ; Kamitani, Shinya ; Kawakami, Shiho ; Ikeda, Osamu ; Muromoto, Ryuta ; Nanbo, Asuka ; Matsuda, Tadashi
著者名 Togi, Sumihito
著者名 Kamitani, Shinya
著者名 Kawakami, Shiho
著者名 Ikeda, Osamu
著者名 Muromoto, Ryuta
著者名 Nanbo, Asuka
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	STAT3
	PP2A
	HDAC3
	dephosphorylation
	transcriptional regulation
発行日	2009-02-06
出版者	Academic Press
収録物名	Biochemical and Biophysical Research Communications
巻(号)	379(2)
ページ	616-620
抄録	Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors, and has been reported to be involved in the pathogenesis of various human diseases. Here, we show that treatment of HeLa cells with a histone deacetylase (HDAC) inhibitor, trichostatin A, or small-interfering RNA (siRNA)-mediated repression of HDAC3, enhances phosphorylation of STAT3 at Ser727. Furthermore, dephosphorylation of STAT3 at Ser727 by protein phosphatase 2A (PP2A) was restored by treatment of cells with HDAC3 siRNA. We further found that formation of a complex between STAT3 and PP2A was enhanced in the presence of HDAC3. Importantly, smallinterfering RNA-mediated repression of both HDAC3 and PP2A effectively enhanced leukemia inhibitory factor (LIF)-induced STAT3 activation. These results indicate that HDAC3 may act as a scaffold protein for PP2A to regulate the LIF/STAT3-mediated signaling pathway.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
EISSN	1090-2104
NCID	AA00564395
関連情報	PMID 19121623
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2008.12.132