Incidence and Risk of Postherpetic Neuralgia after Varicella Zoster Virus Infection in Hematopoietic Cell Transplantation Recipients: Hokkaido Hematology Study Group

Onozawa, Masahiro; Hashino, Satoshi; Haseyama, Yoshifumi et al.

Biology of Blood and Marrow Transplantation, 2009, 15(6), 724-729

Permalink : https://hdl.handle.net/2115/38728

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アクセス権
open access
URI
https://hdl.handle.net/2115/38728
タイトル
Incidence and Risk of Postherpetic Neuralgia after Varicella Zoster Virus Infection in Hematopoietic Cell Transplantation Recipients: Hokkaido Hematology Study Group
著者
Onozawa, Masahiro ; Hashino, Satoshi ; Haseyama, Yoshifumi ; Hirayama, Yasuo ; Iizuka, Susumu ; Ishida, Tadao ; Kaneda, Makoto ; Kobayashi, Hajime ; Kobayashi, Ryoji ; Koda, Kyuhei ; Kurosawa, Mitsutoshi ; Mosauji, Nobuo ; Matsunaga, Takuya ; Mori, Akio ; Mukai, Masaya ; Nishio, Mitsufumi ; Noto, Satoshi ; Ota, Shuichi ; Sakai, Hajime ; Suzuki, Nobuhiro ; Takahashi, Tohru ; Tanaka, Junji ; Torimoto, Yoshihiro ; Yoshida, Makoto ; Fukuhara, Takashi
著者名
Onozawa, Masahiro
著者名
Hashino, Satoshi
著者名
Haseyama, Yoshifumi
著者名
Hirayama, Yasuo
著者名
Iizuka, Susumu
著者名
Ishida, Tadao
著者名
Kaneda, Makoto
著者名
Kobayashi, Hajime
著者名
Kobayashi, Ryoji
著者名
Koda, Kyuhei
著者名
Kurosawa, Mitsutoshi
著者名
Mosauji, Nobuo
著者名
Matsunaga, Takuya
著者名
Mori, Akio
著者名
Mukai, Masaya
著者名
Nishio, Mitsufumi
著者名
Noto, Satoshi
著者名
Ota, Shuichi
著者名
Sakai, Hajime
著者名
Suzuki, Nobuhiro
著者名
Takahashi, Tohru
e-Rad_Researcher
50250452
著者名
Tanaka, Junji
著者名
Torimoto, Yoshihiro
著者名
Yoshida, Makoto
著者名
Fukuhara, Takashi
言語
英語
キーワード
Varicella zoster virus
Postherpetic neuralgia
Disseminated zoster
Visceral zoster
発行日
2009-06
出版者
Elsevier Inc.
収録物名
Biology of Blood and Marrow Transplantation
巻(号)
15(6)
ページ
724-729
抄録
To assess the incidence of and risk factors associated with post-herpetic neuralgia (PHN) after post-hematopoietic cell transplantation (HCT) varicella-zoster virus (VZV) infection, we conducted a retrospective chart review of 418 consecutive patients who underwent HCT between April 2005 and March 2007. Male/female ratio was 221/197, median age at HCT was 47 years (range: 0-69 years), and autologous/allogeneic/syngeneic HCT ratio was 154/263/1. Seventy-eight patients developed VZV infection after HCT. Sixty-two patients had localized zoster, 11 patients had disseminated zoster (rash like chicken pox), and 4 patients had visceral zoster. All cases were treated with acyclovir (ACV) or valacyclovir (VACV), and there was no VZV infection-related death. Twenty-seven (35%) of the 78 patients with VZV infection suffered PHN after resolution of VZV infection. Multivariate analysis showed that advanced age is the only risk factor in autologous HCT (P = 0.0075; OR = 1.14; 95% Cl, 0.97 to 1.33). On the other hand, advanced age (P = 0.0097; OR = 1.06; 95% Cl, 1.01 to 1.12), male gender (P = 0.0055; OR = 12.7; 95% Cl, 1.61 to 100.1), and GVHD prophylaxis with a tacrolimus-based regimen (P = 0.0092; OR = 9.56; 95% Cl, 1.44 to 63.3) were associated with increased risk of PHN in allogeneic HCT. This study for the first time clarified the risk of PHN in HCT recipients.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
1083-8791
関連情報
PMID
19450757
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbmt.2009.03.003