Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients

Horie, Yukihiro; Kitaichi, Nobuyoshi; Katsuyama, Yoshihiko; Yoshida, Kazuhiko; Miura, Toshie; Ota, Masao; Asukata, Yuri; Inoko, Hidetoshi; Mizuki, Nobuhisa; Ishida, Susumu; Ohno, Shigeaki

Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients

Horie, Yukihiro; Kitaichi, Nobuyoshi; Katsuyama, Yoshihiko et al.

Molecular Vision, 2009, 15, 1115-1119

Permalink : https://hdl.handle.net/2115/38776

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アクセス権	open access
URI	https://hdl.handle.net/2115/38776
タイトル	Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients
著者	Horie, Yukihiro ; Kitaichi, Nobuyoshi ; Katsuyama, Yoshihiko ; Yoshida, Kazuhiko ; Miura, Toshie ; Ota, Masao ; Asukata, Yuri ; Inoko, Hidetoshi ; Mizuki, Nobuhisa ; Ishida, Susumu ; Ohno, Shigeaki
著者名 Horie, Yukihiro
e-Rad_Researcher 40431366 著者名 Kitaichi, Nobuyoshi
著者名 Katsuyama, Yoshihiko
e-Rad_Researcher 90281807 著者名 Yoshida, Kazuhiko
著者名 Miura, Toshie
著者名 Ota, Masao
著者名 Asukata, Yuri
著者名 Inoko, Hidetoshi
著者名 Mizuki, Nobuhisa
e-Rad_Researcher 10245558 著者名 Ishida, Susumu
e-Rad_Researcher 50002382 著者名 Ohno, Shigeaki
言語	英語
発行日	2009-06-03
出版者	Molecular Vision
収録物名	Molecular Vision
巻(号)	15
ページ	1115-1119
抄録	Purpose: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder against melanocytes. Polymorphisms of the protein tyrosine phosphatase non-receptor 22 gene (PTPN22) have recently been reported to be associated with susceptibility to several autoimmune diseases. In this study, genetic susceptibility to VKH disease was investigated by screening for single nucleotide polymorphisms (SNPs) of PTPN22. Methods: A total of 167 Japanese patients with VKH disease and 188 healthy Japanese controls were genotyped by direct sequencing methods for six SNPs (rs3811021, rs1217413, rs1237682, rs3761935, rs3789608, and rs2243471) of PTPN22 including the uncoding exons. Results: The six SNPs in PTPN22 showed no significant association with susceptibility to VKH disease or its ocular, neurologic, or dermatological manifestation. Conclusions: Further studies are needed to clarify the genetic mechanisms underlying VKH disease.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1090-0535
関連情報	PMID 19503742