Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2

Ikeda, Osamu; Togi, Sumihito; Kamitani, Shinya et al.

Biological & pharmaceutical bulletin, 2009, 32(7), 1283-1285

Permalink : https://hdl.handle.net/2115/38801

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アクセス権
open access
URI
https://hdl.handle.net/2115/38801
タイトル
Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
著者
Ikeda, Osamu ; Togi, Sumihito ; Kamitani, Shinya ; Muromoto, Ryuta ; Sekine, Yuichi ; Nanbo, Asuka ; Fujimuro, Masahiro ; Matsuda, Tadashi
著者名
Ikeda, Osamu
著者名
Togi, Sumihito
著者名
Kamitani, Shinya
著者名
Muromoto, Ryuta
著者名
Sekine, Yuichi
著者名
Nanbo, Asuka
著者名
Fujimuro, Masahiro
e-Rad_Researcher
20212219
著者名
Matsuda, Tadashi
言語
英語
キーワード
Epstein-Barr virus
Epstein-Barr nuclear antigen 2
SMRT
STAT3
発行日
2009-07
出版者
Pharmaceutical Society of Japan
収録物名
Biological & pharmaceutical bulletin
巻(号)
32(7)
ページ
1283-1285
抄録
The Epstein-Barr virus (EBV)-encoded latency protein Epstein–Barr nuclear antigen 2 (EBNA2) is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. In a previous study, we demonstrated that EBNA2 interacts with signal transducer and activator of transcription 3 (STAT3), a signal transducer for an interleukin (IL)-6 family cytokine, and enhances its transcriptional activity. Here, we show that overexpression of a corepressor, silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), decreases the EBNA2-mediated enhanced STAT3 activation. Furthermore, small-interfering RNA-mediated reduction of endogenous SMRT expression augments the EBNA2-mediated enhanced STAT3 activation. Importantly, EBNA2 reduces interactions between STAT3 and SMRT. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3 by influencing the SMRT corepressor complex.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0918-6158
EISSN
1347-5215
NCID
AA10885497
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/bpb.32.1283