Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma

Yoshioka, T.; Miyamoto, M.; Cho, Y.; Ishikawa, K.; Tsuchikawa, T.; Kadoya, M.; Li, L.; Mishra, R.; Ichinokawa, K.; Shoji, Y.; Matsumura, Y.; Shichinohe, T.; Hirano, S.; Shinohara, T.; Itoh, T.; Kondo, S.

Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma

Yoshioka, T.; Miyamoto, M.; Cho, Y. et al.

British Journal of Cancer, 2008, 98(7), 1258-1263

Permalink : https://hdl.handle.net/2115/39260

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アクセス権	open access
URI	https://hdl.handle.net/2115/39260
タイトル	Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma
著者	Yoshioka, T. ; Miyamoto, M. ; Cho, Y. ; Ishikawa, K. ; Tsuchikawa, T. ; Kadoya, M. ; Li, L. ; Mishra, R. ; Ichinokawa, K. ; Shoji, Y. ; Matsumura, Y. ; Shichinohe, T. ; Hirano, S. ; Shinohara, T. ; Itoh, T. ; Kondo, S.
著者名 Yoshioka, T.
著者名 Miyamoto, M.
著者名 Cho, Y.
著者名 Ishikawa, K.
著者名 Tsuchikawa, T.
著者名 Kadoya, M.
著者名 Li, L.
著者名 Mishra, R.
著者名 Ichinokawa, K.
著者名 Shoji, Y.
著者名 Matsumura, Y.
e-Rad_Researcher 70374353 著者名 Shichinohe, T.
著者名 Hirano, S.
著者名 Shinohara, T.
著者名 Itoh, T.
e-Rad_Researcher 30215454 著者名 Kondo, S.
言語	英語
キーワード	OSCC
	Foxp3
	Treg
	anti-tumour immunity
	prognosis
発行日	2008-04
出版者	Nature Publishing Group
収録物名	British Journal of Cancer
巻(号)	98(7)
ページ	1258-1263
抄録	CD4/8 status has been previously reported to be a critical factor in the prognosis of oesophageal squamous cell carcinoma (OSCC). In the current study, we investigated the effect of regulatory T cells (Treg; Foxp3; lymphocytes) on the status of CD4+ and CD8+ T cells in 122 patients with OSCC. Immunohistochemical analysis of Treg was performed using an antibody against Foxp3. The survival rate for low Foxp3 patients was significantly lower than for high Foxp3 patients (P=0.0028 by log-rank test), but Foxp3 status did not significantly correlate with prognosis in CD4/8(+/+) patients or CD4/8(+/-) or (-/+) patients (P=0.5185 and 0.8479, respectively, by log-rank test). We also found that Foxp3 status correlated with CD4/8 status (P=0.0002 by χ2 test) and that the variance of CD8/CD4 ratio in patients with low Foxp3 was larger than in patients with high Foxp3 (P<0.0001 by F-test). Thus, the results do not support the idea that Treg suppress anti-tumour immunity in patients with OSCC. Rather, the CD8/CD4 ratio and CD4/8 status appear to be critical factors in anti-tumour immunity. Furthermore, Treg numbers correlate with both the CD8/CD4 ratio and the CD4/8 status, suggesting that Treg number is not a factor to predict patient's survival in OSCC.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
PISSN	0007-0920
EISSN	1532-1827
NCID	AA00574355
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/sj.bjc.6604294