Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation

Tanaka, Junji; Sugita, Junichi; Asanuma, Shinsuke; Arita, Kotaro; Shono, Yusuke; Kikutchi, Misato; Shiratori, Souichi; Wakasa, Kentaro; Yasumoto, Atsushi; Shigematu, Akio; Kondo, Takeshi; Kobayashi, Takahiko; Asaka, Masahiro; Imamura, Masahiro

Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation

Tanaka, Junji; Sugita, Junichi; Asanuma, Shinsuke et al.

Human Immunology, 2009, 70(9), 701-705

Permalink : https://hdl.handle.net/2115/39350

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アクセス権	open access
URI	https://hdl.handle.net/2115/39350
タイトル	Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation
著者	Tanaka, Junji ; Sugita, Junichi ; Asanuma, Shinsuke ; Arita, Kotaro ; Shono, Yusuke ; Kikutchi, Misato ; Shiratori, Souichi ; Wakasa, Kentaro ; Yasumoto, Atsushi ; Shigematu, Akio ; Kondo, Takeshi ; Kobayashi, Takahiko ; Asaka, Masahiro ; Imamura, Masahiro
e-Rad_Researcher 50250452 著者名 Tanaka, Junji
著者名 Sugita, Junichi
著者名 Asanuma, Shinsuke
著者名 Arita, Kotaro
著者名 Shono, Yusuke
著者名 Kikutchi, Misato
著者名 Shiratori, Souichi
著者名 Wakasa, Kentaro
著者名 Yasumoto, Atsushi
著者名 Shigematu, Akio
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
著者名 Kobayashi, Takahiko
著者名 Asaka, Masahiro
著者名 Imamura, Masahiro
言語	英語
キーワード	NK cell
	Cord blood transplantation
	Graft-versus-leukemia effect
発行日	2009-09
出版者	Elsevier Inc.
収録物名	Human Immunology
巻(号)	70(9)
ページ	701-705
抄録	In the present study, we investigated subpopulations of NK cells and the expression of stimulatory and inhibitory NK receptors after adult blood and bone marrow transplantation (BBMT) and cord blood transplantation (CBT). There were significant increases in CD16(+)CD56(dim) cell proportion and in absolute number in peripheral blood mononuclear cells (PBMC) during a period of 4 months to 9 months after CBT compared with these in normal PBMC, cord blood (CB), and in PBMC after BBMT. Also, increased numbers of CD16(+)CD56(dim) NK cell sustained in some patients until 4 years after CBT. This CD16(+)CD56(dim) cell subset after CBT exhibited decreased expression of NKG2A compared with that in CB and increased expression of NKG2C. Purified CD16(+)CD56(dim) cells from patients 8-9 months after CBT exhibited significantly higher levels of cytolytic activity against K562 than did purified CD16(+)CD56(bright) cells and also whole PBMC. The CD16(+)CD56(dim) cell subset with a high level of cytolytic activity significantly increased after CBT, and these cells may be responsible for NK cell-mediated immunity after CBT.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0198-8859
関連情報	PMID 19524005
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.humimm.2009.06.002