Inhibitory Activity of (E)-5-(2-Bromovinyl)-2'-Deoxyuridine on the Salmonid Herpesviruses, Oncorhynchus masou Virus (OMV) and Herpesvirus salmonis

Kimura, Takahisa; Nishizawa, Toyohiko; Yoshimizu, Mamoru et al.

Microbiology and Immunology, 1988, 32(1), 57-65

Permalink : https://hdl.handle.net/2115/39476

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アクセス権
open access
URI
https://hdl.handle.net/2115/39476
タイトル
Inhibitory Activity of (E)-5-(2-Bromovinyl)-2'-Deoxyuridine on the Salmonid Herpesviruses, Oncorhynchus masou Virus (OMV) and Herpesvirus salmonis
著者
Kimura, Takahisa ; Nishizawa, Toyohiko ; Yoshimizu, Mamoru ; De Clercq, Erik
e-Rad_Researcher
60001583
著者名
Kimura, Takahisa
e-Rad_Researcher
10222184
著者名
Nishizawa, Toyohiko
e-Rad_Researcher
40122915
著者名
Yoshimizu, Mamoru
著者名
De Clercq, Erik
言語
英語
発行日
1988
出版者
Center for Academic Publications Japan
収録物名
Microbiology and Immunology
巻(号)
32(1)
ページ
57-65
抄録
The highly potent and selective anti-herpesvirus agent, (E)-5-(2-bromovinyl)-2'deoxyuridine (BVdU), was examined for its inhibitory effect on the salmonid herpesviruses Oncorhynchus masou virus (OMV) and Herpesvirus salmonis (H. salmonis). Minimum inhibitory concentrations (MIC) of BVdU for OMV and H. salmonis were 1.25 and 3.0 μg/ml, respectively; these values were equal to or higher than those obtained for acyclovir or cytarabin. OMV DNA polymerase activity was reduced in a dose-dependent fashion by BVdU 5'-triphosphate (BVdUTP) within the concentration range of 3 to 30 μm. However, BVdUTP could also be substituted for the natural substrate, TTP, in the OMV DNA polymerase assay. It is postulated that the inhibitory action of BVdU on the salmonid herpesviruses is more or less similar to that on other herpesviruses and resides with respect to the inhibition of the virus DNA polymerase activity as well as incorporation of BVdU into the viral DNA.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0385-5600