open access

https://hdl.handle.net/2115/39718

Detection of thyroid hormone receptors in the olfactory system and brain of wild masu salmon, Oncorhynchus masou (Brevoort), during smolting by in vitro autoradiography

T3 receptors in masu salmon olfactory system and brain

英語

1994

Blackwell Publishing

Aquaculture and Fisheries Management

25(Supplement 2)

171-182

Thyroid hormone regulates a number of physiological functions during smolting in salmonids. However, the target sites and roles of thyroid hormone in the central nervous system (CNS) are not known in detail. We detected thyroid hormone-specific binding sites (i.e. thyroid hormone receptors) in the olfactory epithelium and the brain (the olfactory bulb, the telencephalon, the mid-brain and the cerebellum) of wild masu salmon, Oncorhynchus masou (Brevoort), during smolting by means of in vitro autoradiography with frozen sections. A saturation experiment with the brain indicated the presence of a single class of binding sites of high affinity. T3-specific binding was detected in the olfactory epithelium and in all regions of the brain except the olfactory bulb. The T3-specific binding value in the olfactory epithelium was higher than in all other regions of the brain. This binding value in the olfactory epithelium increased at the full-smolt stage. The presence of thyroid hormone receptors in various regions of the CNS suggests that thyroid hormone plays an important role in the functional change in the brain and the olfactory epithelium during smolting.

学術雑誌論文

Accepted Manuscript

The definitive version was published by Blackwell Publishing.

1355-557X