Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi, Kanae; Sasaki, Seiko; Kato, Shizue; Ban, Susumu; Washino, Noriaki; Kajiwara, Jumboku; Todaka, Takashi; Hirakawa, Hironori; Hori, Tsuguhide; Yasutake, Daisuke; Kishi, Reiko

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi, Kanae; Sasaki, Seiko; Kato, Shizue et al.

Environmental Research, 2009, 109(7), 906-913

Permalink : https://hdl.handle.net/2115/39727

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アクセス権	open access
URI	https://hdl.handle.net/2115/39727
タイトル	Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight
著者	Konishi, Kanae ; Sasaki, Seiko ; Kato, Shizue ; Ban, Susumu ; Washino, Noriaki ; Kajiwara, Jumboku ; Todaka, Takashi ; Hirakawa, Hironori ; Hori, Tsuguhide ; Yasutake, Daisuke ; Kishi, Reiko
著者名 Konishi, Kanae
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
著者名 Kato, Shizue
e-Rad_Researcher 30399828 著者名 Ban, Susumu
著者名 Washino, Noriaki
著者名 Kajiwara, Jumboku
著者名 Todaka, Takashi
著者名 Hirakawa, Hironori
著者名 Hori, Tsuguhide
著者名 Yasutake, Daisuke
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Birth weight
	Fetal growth
	Dioxin
	Maternal blood
	Prenatal exposure
発行日	2009-10
出版者	Elsevier Inc.
収録物名	Environmental Research
巻(号)	109(7)
ページ	906-913
抄録	Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies. A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood. Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% Cl: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% Cl: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% Cl: -387.4 to -61.5). Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0013-9351
関連情報	PMID 19683226
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envres.2009.07.010