DJ-1 binds to mitochondrial complex I and maintains its activity

Hayashi, Takuya; Ishimori, Chikako; Takahashi-Niki, Kazuko; Taira, Takahiro; Kim, Yun-chul; Maita, Hiroshi; Maita, Chinatsu; Ariga, Hiroyoshi; Iguchi-Ariga, Sanae M. M.

DJ-1 binds to mitochondrial complex I and maintains its activity

Hayashi, Takuya; Ishimori, Chikako; Takahashi-Niki, Kazuko et al.

Biochemical and Biophysical Research Communications, 2009, 390(3), 667-672

Permalink : https://hdl.handle.net/2115/42484

このアイテムのアクセス数:1,758件（2026-05-12 13:01 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
BBRC390-3_667-672	pdf	922 KB	2,449

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/42484
タイトル	DJ-1 binds to mitochondrial complex I and maintains its activity
著者	Hayashi, Takuya ; Ishimori, Chikako ; Takahashi-Niki, Kazuko ; Taira, Takahiro ; Kim, Yun-chul ; Maita, Hiroshi ; Maita, Chinatsu ; Ariga, Hiroyoshi ; Iguchi-Ariga, Sanae M. M.
著者名 Hayashi, Takuya
著者名 Ishimori, Chikako
e-Rad_Researcher 50447645 著者名 Takahashi-Niki, Kazuko
e-Rad_Researcher 70197036 著者名 Taira, Takahiro
著者名 Kim, Yun-chul
e-Rad_Researcher 60431318 著者名 Maita, Hiroshi
著者名 Maita, Chinatsu
e-Rad_Researcher 20143505 著者名 Ariga, Hiroyoshi
e-Rad_Researcher 90184283 著者名 Iguchi-Ariga, Sanae M. M.
言語	英語
キーワード	DJ-1
	Mitochondria
	Parkinson's disease
	Complex I
発行日	2009-12-18
出版者	Elsevier Inc.
収録物名	Biochemical and Biophysical Research Communications
巻(号)	390(3)
ページ	667-672
抄録	Parkinson's disease (PD) is caused by neuronal cell death, and oxidative stress and mitochondrial dysfunction are thought to be responsible for onset of PD. DJ-1, a causative gene product of a familial form of Parkinson's disease, PARK7, plays roles in transcriptional regulation and anti-oxidative stress. The possible mitochondrial function of DJ-1 has been proposed, but its exact function remains unclear. In this study, we found that DJ-1 directly bound to NDUFA4 and ND1, nuclear and mitochondrial DNA-encoding subunits of mitochondrial complex I, respectively, and was co-localized with complex I and that complex I activity was reduced in DJ-1-knockdown NIH3T3 and HEK293 cells. These findings suggest that DJ-1 is an integral mitochondrial protein and that DJ-1 plays a role in maintenance of mitochondrial complex I activity.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
関連情報	PMID 19822128
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2009.10.025