Shrinking and development of lipid droplets in adipocytes during catecholamine-induced lipolysis

Nagayama, Masafumi; Shimizu, Kyoko; Taira, Toshio; Uchida, Tsutomu; Gohara, Kazutoshi

Shrinking and development of lipid droplets in adipocytes during catecholamine-induced lipolysis

Nagayama, Masafumi; Shimizu, Kyoko; Taira, Toshio et al.

FEBS Letters, 2010, 584(1), 86-92

Permalink : https://hdl.handle.net/2115/42552

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アクセス権	open access
URI	https://hdl.handle.net/2115/42552
タイトル	Shrinking and development of lipid droplets in adipocytes during catecholamine-induced lipolysis
著者	Nagayama, Masafumi ; Shimizu, Kyoko ; Taira, Toshio ; Uchida, Tsutomu ; Gohara, Kazutoshi
e-Rad_Researcher 70374585 著者名 Nagayama, Masafumi
著者名 Shimizu, Kyoko
著者名 Taira, Toshio
著者名 Uchida, Tsutomu
著者名 Gohara, Kazutoshi
言語	英語
キーワード	Adipocyte
	Lipid droplet
	Norepinephrine
	Adipose triglyceride lipase (ATGL)
	Hormone-sensitive lipase (HSL)
	Time-lapse observation
発行日	2010-01-04
出版者	Elsevier B.V.
収録物名	FEBS Letters
巻(号)	584(1)
ページ	86-92
抄録	Time-lapse observation of adipocytes during catecholamine-induced lipolysis clearly shows that shrinking of existing lipid droplets (LDs) occurs in some adipocytes and that small LDs are newly developed in almost all cells. Immunofluorescence imaging reveals that activation and localization of hormone-sensitive lipase (HSL) on the surface of LDs, which are required for conferring maximal lipolysis, are necessary for the shrinking of the LDs. However, not all adipocytes in which phosphorylated HSL is localized on LDs exhibit shrinking of LDs. The simultaneous shrinking and development of LDs yield apparent fragmentation and dispersion of LDs in adipocytes stimulated with catecholamine.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0014-5793
関連情報	PMID 19896941
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.febslet.2009.10.088