TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

Kikuchi, Misato; Okumura, Fumihiko; Tsukiyama, Tadasuke; Watanabe, Masashi; Miyajima, Naoto; Tanaka, Junji; Imamura, Masahiro; Hatakeyama, Shigetsugu

TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

Kikuchi, Misato; Okumura, Fumihiko; Tsukiyama, Tadasuke et al.

Biochimica et Biophysica Acta (BBA) : Molecular Cell Research, 2009, 1793(12), 1828-1836

Permalink : https://hdl.handle.net/2115/42555

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アクセス権	open access
URI	https://hdl.handle.net/2115/42555
タイトル	TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells
著者	Kikuchi, Misato ; Okumura, Fumihiko ; Tsukiyama, Tadasuke ; Watanabe, Masashi ; Miyajima, Naoto ; Tanaka, Junji ; Imamura, Masahiro ; Hatakeyama, Shigetsugu
著者名 Kikuchi, Misato
著者名 Okumura, Fumihiko
著者名 Tsukiyama, Tadasuke
著者名 Watanabe, Masashi
著者名 Miyajima, Naoto
著者名 Tanaka, Junji
著者名 Imamura, Masahiro
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
キーワード	TRIM24
	Androgen receptor
	Prostate cancer
	BRD7
発行日	2009-12
出版者	Elsevier B.V.
収録物名	Biochimica et Biophysica Acta (BBA) : Molecular Cell Research
巻(号)	1793(12)
ページ	1828-1836
抄録	The androgen receptor (AR) is a ligand-dependent transcription factor that belongs to the family of nuclear receptors, and its activity is regulated by numerous AR coregulators. AR plays an important role in prostate development and cancer. In this study, we found that TRIM24/transcriptional intermediary factor 1α (TIF1α), which is known as a ligand-dependent nuclear receptor co-regulator, interacts with AR and enhances transcriptional activity of AR by dihydrotestosterone in prostate cancer cells. We showed that TRIM24 functionally interacts with TIP60, which acts as a coactivator of AR and synergizes with TIP60 in the transactivation of AR. We also showed that TRIM24 binds to bromodomain containing 7 (BRD7), which can negatively regulate cell proliferation and growth. A luciferase assay indicated that BRD7 represses the AR transactivation activity upregulated by TRIM24. These findings indicate that TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0167-4889
関連情報	PMID 19909775
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbamcr.2009.11.001