Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives

Masuda, Katsuyoshi; Koizumi, Ayako; Misaka, Takumi et al.

Bioorganic & Medicinal Chemistry Letters, 2010, 20(3), 1081-1083

Permalink : https://hdl.handle.net/2115/42636

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アクセス権	open access
URI	https://hdl.handle.net/2115/42636
タイトル	Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives
著者	Masuda, Katsuyoshi ; Koizumi, Ayako ; Misaka, Takumi ; Hatanaka, Yasumaru ; Abe, Keiko ; Tanaka, Takaharu ; Ishiguro, Masaji ; Hashimoto, Makoto
著者名 Masuda, Katsuyoshi
著者名 Koizumi, Ayako
著者名 Misaka, Takumi
著者名 Hatanaka, Yasumaru
著者名 Abe, Keiko
著者名 Tanaka, Takaharu
著者名 Ishiguro, Masaji
著者名 Hashimoto, Makoto
言語	英語
キーワード	Sweet taste
	D-Amino acid
	Photoaffinity label
	Diazirine
発行日	2010-02-01
出版者	Elsevier
収録物名	Bioorganic & Medicinal Chemistry Letters
巻(号)	20(3)
ページ	1081-1083
抄録	Some D-Amino acids such as D-tryptophan and D-phenylalanine are well known as naturally-occurring sweeteners. Photoreactive D-phenylalanine derivatives containing trifluoromethyldiazirinyl moiety at 3- or 4-position of phenylalanine, were designed as sweeteners for functional analysis with photoaffinity labeling. The trifluoromethyldiazirinyl D-phenylalanine derivatives were prepared effectively with chemo-enzymatic methods using L-amino acid oxidase and were found to have potent activity toward the human sweet taste receptor.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0960-894X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bmcl.2009.12.029