BS69 cooperates with TRAF3 in the regulation of Epstein–Barr virus-derived LMP1/CTAR1-induced NF-κB activation

Ikeda, Osamu; Miyasaka, Yuto; Yoshida, Ryuji; Mizushima, Akihiro; Oritani, Kenji; Sekine, Yuichi; Kuroda, Makoto; Yasui, Teruhito; Fujimuro, Masahiro; Muromoto, Ryuta; Nanbo, Asuka; Matsuda, Tadashi

BS69 cooperates with TRAF3 in the regulation of Epstein–Barr virus-derived LMP1/CTAR1-induced NF-κB activation

Ikeda, Osamu; Miyasaka, Yuto; Yoshida, Ryuji et al.

FEBS Letters, 2010, 584(5), 865-872

Permalink : https://hdl.handle.net/2115/42639

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アクセス権	open access
URI	https://hdl.handle.net/2115/42639
タイトル	BS69 cooperates with TRAF3 in the regulation of Epstein–Barr virus-derived LMP1/CTAR1-induced NF-κB activation
その他のタイトル	Physical and functional interactions between BS69 and LMP1/CTAR1
著者	Ikeda, Osamu ; Miyasaka, Yuto ; Yoshida, Ryuji ; Mizushima, Akihiro ; Oritani, Kenji ; Sekine, Yuichi ; Kuroda, Makoto ; Yasui, Teruhito ; Fujimuro, Masahiro ; Muromoto, Ryuta ; Nanbo, Asuka ; Matsuda, Tadashi
著者名 Ikeda, Osamu
著者名 Miyasaka, Yuto
著者名 Yoshida, Ryuji
著者名 Mizushima, Akihiro
著者名 Oritani, Kenji
e-Rad_Researcher 20396295 著者名 Sekine, Yuichi
著者名 Kuroda, Makoto
著者名 Yasui, Teruhito
著者名 Fujimuro, Masahiro
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
e-Rad_Researcher 60359487 著者名 Nanbo, Asuka
著者名 Matsuda, Tadashi
言語	英語
キーワード	BS69
	EBV
	LMP1
	TRAF3
	NF-κB
	transcription
発行日	2010-03-05
出版者	Elsevier
収録物名	FEBS Letters
巻(号)	584(5)
ページ	865-872
抄録	Epstein-Barr virus latent membrane protein 1 (LMP1) activates NF-κB signaling pathways through two C-terminal regions, CTAR1 and CTAR2. Previous studies have demonstrated that BS69, a multidomain cellular protein, regulates LMP1/CTAR2-mediated NF-κB activation by interfering with the complex formation between TRADD and LMP1/CTAR2. Here, we found that BS69 directly interacted with the LMP1/CTAR1 domain and regulated LMP1/CTAR1-mediated NF-κB activation and subsequent IL-6 production. Regarding the mechanisms involved, we found that BS69 directly interacted with TRAF3, a negative regulator of NF-κB activation. Furthermore, small-interfering RNA-mediated knockdown experiments revealed that TRAF3 was involved in the BS69-mediated suppression of LMP1/CTAR1-induced NF-κB activation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0014-5793
NCID	AA00642943
関連情報	PMID 20138174
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.febslet.2010.01.060