IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells

Kubota, Nobuhiko; Ebihara, Takashi; Matsumoto, Misako; Gando, Satoshi; Seya, Tsukasa

IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells

Kubota, Nobuhiko; Ebihara, Takashi; Matsumoto, Misako et al.

Biochemical and Biophysical Research Communications, 2010, 391(3), 1421-1426

Permalink : https://hdl.handle.net/2115/42641

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アクセス権	open access
URI	https://hdl.handle.net/2115/42641
タイトル	IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells
著者	Kubota, Nobuhiko ; Ebihara, Takashi ; Matsumoto, Misako ; Gando, Satoshi ; Seya, Tsukasa
著者名 Kubota, Nobuhiko
著者名 Ebihara, Takashi
著者名 Matsumoto, Misako
著者名 Gando, Satoshi
著者名 Seya, Tsukasa
言語	英語
キーワード	TICAM-1 (TRIF)
	Interferon-alpha
	IL-6
	Dendritic cells
	Regulatory T cells (Treg)
発行日	2010-01-15
出版者	Elsevier
収録物名	Biochemical and Biophysical Research Communications
巻(号)	391(3)
ページ	1421-1426
抄録	Foxp3+CD4+ regulatory T cells (Treg) control not only autoinimunity but also the effective immune response against RNA virus infections, which produces virus-derived double-stranded RNA (dsRNA). To induce effective anti-viral immunity, it is a key issue to learn how Treg respond to dsRNA in vitro and in vivo. We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). In addition, the expansion of Treg by IL-6 was inhibited by IFN-α from polyI:C-stimulated DCs. These data suggest that the balance of IL-6 and IFN-α in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
関連情報	PMID 20026056
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2009.12.081