TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth

Watanabe, Masashi; Tsukiyama, Tadasuke; Hatakeyama, Shigetsugu

TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth

Watanabe, Masashi; Tsukiyama, Tadasuke; Hatakeyama, Shigetsugu

Biochemical and Biophysical Research Communications, 2009, 388(2), 422-427

Permalink : https://hdl.handle.net/2115/42700

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アクセス権	open access
URI	https://hdl.handle.net/2115/42700
タイトル	TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth
著者	Watanabe, Masashi ; Tsukiyama, Tadasuke ; Hatakeyama, Shigetsugu
著者名 Watanabe, Masashi
著者名 Tsukiyama, Tadasuke
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
キーワード	TRIM31
	Ubiquitin
	p52Shc
	Gastrointestinal tract
	TRIM family
発行日	2009-10-16
出版者	Elsevier
収録物名	Biochemical and Biophysical Research Communications
巻(号)	388(2)
ページ	422-427
抄録	Tripartite motif-containing protein (TRIM) family proteins are involved in a broad range of biological processes and, consistently, their alterations result in diverse pathological conditions such as genetic diseases, viral infection and cancer development. In this study, we found that one of the TRIM family proteins, TRIM31, is highly expressed in the gastrointestinal tract and interacts with p52Shc, one of the signal transducers. We also found by a binding assay that almost the whole region other than the RING domain is required for the binding to p52Shc but found by pulse-chase analysis that overexpression of TRIM31 does not affect the stability of p52Shc. Moreover, we found that overexpression of TRIM31 suppresses anchorage-independent cell growth induced by the active form of c-Src. These results suggest that TRIM31 attenuates c-Src signaling via p52Shc under anchorage-independent growth conditions and is potentially associated with growth activity of cells in the gastrointestinal tract.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
関連情報	PMID 19665990
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2009.08.028