Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma

Takahashi, Osamu; Hamada, Jun-ichi; Abe, Motoki et al.

Oncology Reports, 2007, 17(4), 753-760

Permalink : https://hdl.handle.net/2115/42833

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アクセス権
open access
URI
https://hdl.handle.net/2115/42833
タイトル
Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma
著者
Takahashi, Osamu ; Hamada, Jun-ichi ; Abe, Motoki ; Hata, Shinya ; Asano, Toshimichi ; Takahashi, Yoko ; Tada, Mitsuhiro ; Miyamoto, Masaki ; Kondo, Satoshi ; Moriuchi, Tetsuya
著者名
Takahashi, Osamu
著者名
Hamada, Jun-ichi
著者名
Abe, Motoki
著者名
Hata, Shinya
著者名
Asano, Toshimichi
著者名
Takahashi, Yoko
著者名
Tada, Mitsuhiro
著者名
Miyamoto, Masaki
e-Rad_Researcher
30215454
著者名
Kondo, Satoshi
著者名
Moriuchi, Tetsuya
言語
英語
キーワード
homeobox gene
HOX
real-time RT-PCR
esophageal cancer
ParaHOX
発行日
2007-04
出版者
Spandidos Publications
収録物名
Oncology Reports
巻(号)
17(4)
ページ
753-760
抄録
Homeobox genes function as master regulators in embryonic morphogenesis. We hypothesized that homeobox genes are essential to maintain tissue- or organ-specificity even in adult body and that the dysregulated expression of homeobox genes results in tumor development and progression. To better understand the roles of homeobox genes in development and progression of esophageal cancer, we analyzed the expression patterns of 39 HOX genes and 4 ParaHOX (CDX1, CDX2, CDX4 and PDX1) genes in esophageal squamous cell carcinoma (ESCC) and normal esophageal mucosa tissues. A total of 48 primary ESCC tissues and 7 normal esophageal mucosa tissues were resected from patients who underwent radical surgery without any preoperative chemotherapy or radiotherapy. The expression of HOX and ParaHOX genes were analyzed by a quantitative real-time RT-PCR method and immunohistochemistry. The expression levels of 24 HOX genes, CDX1, CDX2 and PDX1 were significantly higher in ESCC compared to normal mucosa (p<0.01, Mann-Whitney U test). The Immunohistochemical study revealed that HOXA5 and D9 proteins were more cytoplasmic in ESCC than normal mucosa cells. Our data indicate that the disordered expression of HOX and ParaHOX genes are involved in the development of ESCC or its malignancy.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1021-335X
EISSN
1791-2431