MEG time-frequency analyses for pre- and post-surgical evaluation of patients with epileptic rhythmic fast activity

Sueda, Keitaro; Takeuchi, Fumiya; Shiraishi, Hideaki; Nakane, Shingo; Asahina, Naoko; Kohsaka, Shinobu; Nakama, Hideyuki; Otsuki, Taisuke; Sawamura, Yutaka; Saitoh, Shinji

MEG time-frequency analyses for pre- and post-surgical evaluation of patients with epileptic rhythmic fast activity

Sueda, Keitaro; Takeuchi, Fumiya; Shiraishi, Hideaki et al.

Epilepsy Research, 2010, 88(2-3), 100-107

Permalink : https://hdl.handle.net/2115/42851

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アクセス権	open access
URI	https://hdl.handle.net/2115/42851
タイトル	MEG time-frequency analyses for pre- and post-surgical evaluation of patients with epileptic rhythmic fast activity
著者	Sueda, Keitaro ; Takeuchi, Fumiya ; Shiraishi, Hideaki ; Nakane, Shingo ; Asahina, Naoko ; Kohsaka, Shinobu ; Nakama, Hideyuki ; Otsuki, Taisuke ; Sawamura, Yutaka ; Saitoh, Shinji
著者名 Sueda, Keitaro
著者名 Takeuchi, Fumiya
著者名 Shiraishi, Hideaki
著者名 Nakane, Shingo
著者名 Asahina, Naoko
著者名 Kohsaka, Shinobu
著者名 Nakama, Hideyuki
著者名 Otsuki, Taisuke
著者名 Sawamura, Yutaka
著者名 Saitoh, Shinji
言語	英語
キーワード	Magnetoencephalography
	Fast activity
	Fourier transform
	Time-frequency analysis
	Symptomatic localization-related epilepsy
	Surgical evaluation
発行日	2010-02
出版者	Elsevier B.V.
収録物名	Epilepsy Research
巻(号)	88(2-3)
ページ	100-107
抄録	Purpose: To evaluate the effectiveness of surgery for epilepsy, we analyzed rhythmic fast activity by magnetoencephalography (MEG) before and after surgery using time-frequency analysis. To assess reliability, the results obtained by pre-surgical MEG and intraoperative electrocorticography were compared. Methods: Four children with symptomatic localization-related epilepsy caused by circumscribed cortical lesion were examined in the present study using 204 channel helmet-shaped MEG with a sampling rate of 600 Hz. One patient had dysembryoplastic neuroepithelial tumor (DNT) and three patients had focal cortical dysplasia (FCD). Aberrant areas were superimposed, to reconstruct 3-D MRI images, and illustrated as moving images. Results: In three patients, short-time Fourier transform (STFT) analyses of MEG showed rhythmic activities just above the lesion with FCD and in the vicinity of DNT. In one patient with FCD in the medial temporal lobe, rhythmic activity appeared in the ipsilateral frontal lobe and temporal lateral aspect. These findings correlate well with the results obtained by intraoperative electrocorticography. After the surgery, three patients were relieved of their seizures, and the area of rhythmic MEG activity disappeared or become smaller. One patient had residual rhythmic MEG activity, and she suffered from seizure relapse. Conclusion: Time-frequency analyses using STFT successfully depicted MEG rhythmic fast activity, and would provide valuable information for pre- and post-surgical evaluations to define surgical strategies for patients with epilepsy.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0920-1211
関連情報	PMID 19896803
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.eplepsyres.2009.10.002