Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Araki, Atsuko; Kawai, Toshio; Eitaki, Yoko et al.

Science of The Total Environment, 2010, 408(10), 2208-2215

Permalink : https://hdl.handle.net/2115/43013

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アクセス権
open access
URI
https://hdl.handle.net/2115/43013
タイトル
Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes
著者
Araki, Atsuko ; Kawai, Toshio ; Eitaki, Yoko ; Kanazawa, Ayako ; Morimoto, Kanehisa ; Nakayama, Kunio ; Shibata, Eiji ; Tanaka, Masatoshi ; Takigawa, Tomoko ; Yoshimura, Takesumi ; Chikara, Hisao ; Saijo, Yasuaki ; Kishi, Reiko
e-Rad_Researcher
00619885
著者名
Araki, Atsuko
著者名
Kawai, Toshio
著者名
Eitaki, Yoko
e-Rad_Researcher
90201425
著者名
Kanazawa, Ayako
e-Rad_Researcher
20143414
著者名
Morimoto, Kanehisa
e-Rad_Researcher
80346197
著者名
Nakayama, Kunio
e-Rad_Researcher
90206128
著者名
Shibata, Eiji
著者名
Tanaka, Masatoshi
e-Rad_Researcher
90403493
著者名
Takigawa, Tomoko
e-Rad_Researcher
20037435
著者名
Yoshimura, Takesumi
著者名
Chikara, Hisao
e-Rad_Researcher
70360906
著者名
Saijo, Yasuaki
e-Rad_Researcher
80112449
著者名
Kishi, Reiko
言語
英語
キーワード
Microbial volatile organic compounds (MVOC)
Exposure
Indoors
Home environment
Sick building syndrome
Mucous membrane
Symptoms
Questionnaires
発行日
2010-04-15
出版者
Elsevier B.V.
収録物名
Science of The Total Environment
巻(号)
408(10)
ページ
2208-2215
抄録
Micro-organisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation. However, the effect of MVOC on inhabitants due to household exposure is still unclear. The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS). All inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms. Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry - selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78.6% and geometric mean of 0.60 μg/m3. Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4.8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC. whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log10-unit: odds ratio (OR) 5.6, 95% confidence interval (CI): 2.1 to 14.8) and 2-pentanol (per log10-unit: OR 2.3, 95% CI: 1.0 to 4.9) were obtained after adjustment for gender, age, and smoking. Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0048-9697
関連情報
PMID
20188399
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.scitotenv.2010.02.012