open access

https://hdl.handle.net/2115/43015

Cognitive Signals in the Primate Motor Thalamus Predict Saccade Timing

英語

primate

2007-10-31

Society for Neuroscience

Journal of Neuroscience

27(44)

12109-12118

We often generate movements without any external event that immediately triggers them. How the brain decides the timing of selfinitiated movements remains unclear. Previous studies suggest that the basal ganglia–thalamocortical pathways play this role, but the subcortical signals that determine movement timing have not been identified. The present study reports that a subset of thalamic neurons predicts the timing of self-initiated saccadic eye movements. When monkeys made a saccade in response to the fixation point (FP) offset in the traditional memory saccade task, neurons in the ventrolateral and the ventroanterior nuclei of the thalamus exhibited a gradual buildup of activity that peaked around the most probable time of the FP offset; however, neither the timing nor the magnitude of neuronal activity correlated with saccade latencies, suggesting that the brain is unlikely to have used this information to decide the times of saccades in the traditional memory saccade task. In contrast, when monkeys were required to make a self-timed saccade within a fixed time interval after an external cue, the same neurons again exhibited a strong buildup of activity that preceded saccades by several hundred milliseconds, showing a close correlation between the times of neuronal activity and the times of self-initiated saccades. The results suggest that neurons in the motor thalamus carry subjective time information, which is used by cortical networks to determine the timing of self-initiated saccades.

学術雑誌論文

Version of Record

0270-6474

1529-2401