open access

https://hdl.handle.net/2115/43032

Low prevalence of juvenile-onset Behçet's disease with uveitis in East/South Asian people

英語

Epidemiology

2009-11

BMJ Publishing Group

British Journal of Ophthalmology

93(11)

1428-1430

第1回アジア太平洋内眼炎症学会最高貢献賞若手研究者賞受賞（国際ぶどう膜炎/アジア太平洋内眼炎合同シンポジウムにて、平成21年11月5日～7日、中国・重慶市）

Purpose: There is little information on the demographic and clinical characteristics of Behcet's disease in children in different parts of the world. We sought to provide this information through a questionnaire survey of specialist eye centres. Methods: Descriptive questionnaires were collected from 25 eye centers in 14 countries. The questionnaire surveyed details of juvenile-onset Behcet's disease with uveitis. Ethnic groups, clinical features, treatments, and prognosis of pediatric-age Behcet's disease were examined on a world scale. Results: The clinical data of 135 juvenile-onset and 1,227 adult-onset patients with uveitis were collected. The average age of disease diagnosis in the children was 11.7 years old. Of the ethnic groups identified: 54% were from Middle East, 43% from Europe, but only 2% from East/South Asian countries. By contrast, 19.2% of adult patients were from East or South Asia. The frequency of genital ulcers in juvenile patients was 38.7%, which was significantly lower than in adult cases (53.5%; p < 0.01). Conclusions: Behcet's disease with uveitis was less common in children than in adults in East/South Asia. Although the clinical features of the systemic disease were similar in children and adults, there was a lower frequency of genital ulceration in children.

学術雑誌論文

Accepted Manuscript

This article has been accepted for publication in BJO following peer review. The definitive copyedited, typeset version Br J Ophthalmol 2009;93:1428-1430 is available online at : http://bjo.bmjjournals.com/

0007-1161