open access

https://hdl.handle.net/2115/43035

The Administration of Ciprofloxacin During Continuous Renal Replacement Therapy : Pilot Study

英語

2009-05

Lippincott Williams & Wilkins

ASAIO Journal

55(3)

243-245

Continuous renal replacement therapy (CRRT) is a common technique in critically ill patients. However, there is no uniformity in the pharmacokinetics of ciprofloxacin (CPFX) used during CRRT. The aims of the present study were to estimate the pharmacokinetics of CPFX and to determine the appropriate administration of CPFX for critically ill patients undergoing CRRT. CPFX total clearance (CLtot) was calculated based on the creatinine clearance (CLcre), dialysate flow (QD) and ultrafiltrate flow (QF) as follow: CL_[tot (l/h)] = (4.83 CL_[cre (l/h)] + 6.41) + 0.92 (QD+Q_[F (l/h)]) base on in vitro study using CRRT circuit model. We administered CPFX to critically ill patients based on the CLtot, which was 50 x CL_[tot (l/h)] (mg/day). We confirmed that the CPFX concentrations reached higher than optimal concentrations and the infections were all successfully controlled in these patients.

学術雑誌論文

Accepted Manuscript

This is a non-final version of an article published in final form in ASAIO Journal. 55(3):243-245, May/June 2009

1058-2916