Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study

Sakurai, Kotaro; Takeda, Youji; Tanaka, Naoaki; Kurita, Tsugiko; Shiraishi, Hideaki; Takeuchi, Fumiya; Nakane, Shingo; Sueda, Keitaro; Koyama, Tsukasa

Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study

Sakurai, Kotaro; Takeda, Youji; Tanaka, Naoaki et al.

Epilepsy Research, 2010, 89(2-3), 176-184

Permalink : https://hdl.handle.net/2115/43098

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アクセス権	open access
URI	https://hdl.handle.net/2115/43098
タイトル	Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study
著者	Sakurai, Kotaro ; Takeda, Youji ; Tanaka, Naoaki ; Kurita, Tsugiko ; Shiraishi, Hideaki ; Takeuchi, Fumiya ; Nakane, Shingo ; Sueda, Keitaro ; Koyama, Tsukasa
著者名 Sakurai, Kotaro
著者名 Takeda, Youji
著者名 Tanaka, Naoaki
著者名 Kurita, Tsugiko
著者名 Shiraishi, Hideaki
著者名 Takeuchi, Fumiya
著者名 Nakane, Shingo
著者名 Sueda, Keitaro
著者名 Koyama, Tsukasa
言語	英語
キーワード	Generalized spike-wave discharges
	Absence epilepsy
	Magnetoencephalography
	Default mode network
	Dynamic statistical parametric mapping
発行日	2010-05
出版者	Elsevier B.V.
収録物名	Epilepsy Research
巻(号)	89(2-3)
ページ	176-184
抄録	This study uses magnetoencephalography (MEG) to examine whether cortical regions that constitute a default mode network are involved during generalized spike-wave discharges (GSWs) in patients with juvenile absence epilepsy (JAE). We studied five JAE patients for whom MEG was recorded using a 204-channel, whole-head gradiometer system. Dynamic statistical parametric mapping (dSPM) was done to estimate the cortical source distribution of GSW. The dSPM results showed strong medial prefrontal activation in all patients, with activation in the posterior cingulate and precuneus in three of five patients simultaneously or slightly after medial prefrontal activation. Furthermore, dSPM showed that the initial activation of a GSW appears in the focal cortical regions. Cortical regions that constitute a default mode network are strongly involved in the GSW process in some patients with JAE. Results also show that focal cortical activation appears at the onset of a GSW.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0920-1211
関連情報	PMID 20061122
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.eplepsyres.2009.12.004