Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction

Tosa, Noriko; Iwai, Atsushi; Tanaka, Taku; Kumagai, Tomoka; Nitta, Takeshi; Chiba, Satoko; Maeda, Masahiro; Takahama, Yousuke; Uede, Toshimitsu; Miyazaki, Tadaaki

Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction

Tosa, Noriko; Iwai, Atsushi; Tanaka, Taku et al.

Biochemical and Biophysical Research Communications, 2010, 395(3), 356-360

Permalink : https://hdl.handle.net/2115/43099

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/43099
タイトル	Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction
著者	Tosa, Noriko ; Iwai, Atsushi ; Tanaka, Taku ; Kumagai, Tomoka ; Nitta, Takeshi ; Chiba, Satoko ; Maeda, Masahiro ; Takahama, Yousuke ; Uede, Toshimitsu ; Miyazaki, Tadaaki
e-Rad_Researcher 20312415 著者名 Tosa, Noriko
著者名 Iwai, Atsushi
著者名 Tanaka, Taku
著者名 Kumagai, Tomoka
著者名 Nitta, Takeshi
著者名 Chiba, Satoko
著者名 Maeda, Masahiro
著者名 Takahama, Yousuke
著者名 Uede, Toshimitsu
e-Rad_Researcher 60272431 著者名 Miyazaki, Tadaaki
言語	英語
キーワード	Apoptosis
	Death-associated protein 3
	Negative selection
	Nur77
	T cell receptor
発行日	2010-05-07
出版者	Elsevier
収録物名	Biochemical and Biophysical Research Communications
巻(号)	395(3)
ページ	356-360
抄録	Death associated protein 3 (DAP3) is crucial for promoting apoptosis induced by various stimulations. This report demonstrates that DAP3 is also important for T cell receptor (TCR)-mediated apoptosis induction in immature thymocytes. Enforced expression of DAP3 accelerated the negative selection in developing thymocytes, using the reaggregate thymus organ culture system. In addition, expression of DAP3 accelerated TCR-mediated apoptosis induction in DO11.10 cells. We also demonstrated that DAP3 translocates into the nucleus during TCR-mediated apoptosis in a Nur77 dependent manner. It is concluded that DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
関連情報	PMID 20381457
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2010.04.018