Comparison of warfarin sensitivity between rat and bird species

Watanabe, Kensuke P.; Saengtienchai, Aksorn; Tanaka, Kazuyuki D.; Ikenaka, Yoshinori; Ishizuka, Mayumi

Comparison of warfarin sensitivity between rat and bird species

Watanabe, Kensuke P.; Saengtienchai, Aksorn; Tanaka, Kazuyuki D. et al.

Comparative Biochemistry and Physiology Part C : Toxicology & Pharmacology, 2010, 152(1), 114-119

Permalink : https://hdl.handle.net/2115/43139

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/43139
タイトル	Comparison of warfarin sensitivity between rat and bird species
著者	Watanabe, Kensuke P. ; Saengtienchai, Aksorn ; Tanaka, Kazuyuki D. ; Ikenaka, Yoshinori ; Ishizuka, Mayumi
著者名 Watanabe, Kensuke P.
著者名 Saengtienchai, Aksorn
著者名 Tanaka, Kazuyuki D.
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Avian
	Cytochrome P450 (CYP)
	Inhibitor constant (Ki)
	Raptor
	Vitamin K epoxide reductase (VKOR)
	Vitamin K
	Warfarin
発行日	2010-06
出版者	Elsevier
収録物名	Comparative Biochemistry and Physiology Part C : Toxicology & Pharmacology
巻(号)	152(1)
ページ	114-119
抄録	Scattering coumarin-derivative rodenticides in broad areas have caused primary- and secondary-poisoning incidents in non-target wild birds. In this study, we compared factors determining warfarin sensitivity between bird species and rats based on vitamin K 2,3-epoxide reductase (VKOR) kinetics, VKOR inhibition by warfarin and warfarin metabolism assays. In VKOR characterization, chickens and ostriches showed significantly lower enzymatic efficiencies than rats (one-sixth and one-third, respectively), suggesting bird species depend more on a non-VKOR vitamin K source. On the other hand, the inhibition constants (Ki) of VKOR for warfarin were significantly different between chickens and ostriches (113 ± 2.5 μM and 0.64 ± 0.39 μM, respectively). Interestingly, the ostrich Ki was similar to the values for rats (0.28 ± 0.09 μM). The Ki results reveal a surprising possibility that VKOR in some bird species are easily inhibited by warfarin. Warfarin metabolism assays also showed a large inter-species difference in bird species. Chickens and ostriches showed higher metabolic activity than that of rats, while mallards and owls showed only a slight ability to metabolize warfarin. In this study, we clarified the wide inter-species difference that exists among birds in xenobiotic metabolism and sensitivity to a rodenticide.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1532-0456
関連情報	PMID 20346414
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.cbpc.2010.03.006