Clinical Value and Limitations of [11C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas

Herrmann, Ken; Takei, Toshiki; Kanegae, Kakuko; Shiga, Tohru; Buck, Andreas K.; Altomonte, Jennifer; Schwaiger, Markus; Schuster, Tibor; Nishijima, Kenichi; Kuge, Yuji; Tamaki, Nagara

Clinical Value and Limitations of [11C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas

Herrmann, Ken; Takei, Toshiki; Kanegae, Kakuko et al.

Molecular Imaging and Biology, 2009, 11(5), 356-363

Permalink : https://hdl.handle.net/2115/43808

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アクセス権	open access
URI	https://hdl.handle.net/2115/43808
タイトル	Clinical Value and Limitations of [11C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas
著者	Herrmann, Ken ; Takei, Toshiki ; Kanegae, Kakuko ; Shiga, Tohru ; Buck, Andreas K. ; Altomonte, Jennifer ; Schwaiger, Markus ; Schuster, Tibor ; Nishijima, Kenichi ; Kuge, Yuji ; Tamaki, Nagara
著者名 Herrmann, Ken
著者名 Takei, Toshiki
e-Rad_Researcher 30326855 著者名 Kanegae, Kakuko
e-Rad_Researcher 80374495 著者名 Shiga, Tohru
著者名 Buck, Andreas K.
著者名 Altomonte, Jennifer
著者名 Schwaiger, Markus
著者名 Schuster, Tibor
著者名 Nishijima, Kenichi
e-Rad_Researcher 70321958 著者名 Kuge, Yuji
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
言語	英語
キーワード	MET-PET
	MIBI scintigraphy
	Ultrasound
	Hyperparathyroidism
	Diagnosis
発行日	2009-09
出版者	Springer New York
収録物名	Molecular Imaging and Biology
巻(号)	11(5)
ページ	356-363
抄録	Purpose: The aim of this study was to assess the clinical value of [11C]methionine-PET (MET-PET) for detection and localization of parathyroid adenomas in patients without prior thyroidectomy. Methods: A retrospective analysis of patients with suspected hyperparathyroidism undergoing imaging with MET-PET was performed. Prior thyroidectomy was an exclusion criterion. 41 patients with a total of 49 MET-PET scans were included. MET-PET consisted of whole-body images obtained 15 - 20 min after injection of 430 ± 81 MBq of MET using a dedicated PET scanner. Imaging findings were validated by histology or other imaging studies and clinical follow-up on a lesion, side and location basis. Comparison of PET results to other imaging modalities including ultrasound, MIBI scintigraphy and morphological imaging (CT and/or MRI) and subgroup analysis of primary vs. secondary hyperparathyroidism was performed. Results: 23/49 PET scans revealed pathologic findings, whereas 26/49 scans were negative. Validation of PET findings for detection and localization of hyperthyroidism resulted in an overall sensitivity of MET-PET of 54%, 49% and 35% on a lesion, side and location basis, respectively. Sensitivity of MET-PET was inferior compared to ultrasonography (50% vs. 93%), MIBI scintigraphy (53% vs. 74%) and morphological imaging (52% vs. 74%). Subgroup analysis revealed higher sensitivity for MET-PET in sHPT than pHPT (62% vs. 43%; side basis). Conclusions: In patients with initial diagnosis of hyperparathyroidism and no prior thyroidectomy, the sensitivity of MET-PET for detection and localization of hyperparathyroidism is markedly lower compared to previous reports. While performance was better in sHPT, MET-PET can not be recommended for pHPT localization in this clinically relevant subcollective.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	1536-1632
関連情報	PMID 19340488
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11307-009-0205-4