Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells

Ohga, Noritaka; Hida, Kyoko; Hida, Yasuhiro; Muraki, Chikara; Tsuchiya, Kunihiko; Matsuda, Kohei; Ohiro, Yoichi; Totsuka, Yasunori; Shindoh, Masanobu

Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells

Ohga, Noritaka; Hida, Kyoko; Hida, Yasuhiro et al.

Cancer Science, 2009, 100(10), 1963-1970

Permalink : https://hdl.handle.net/2115/43937

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アクセス権	open access
URI	https://hdl.handle.net/2115/43937
タイトル	Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells
著者	Ohga, Noritaka ; Hida, Kyoko ; Hida, Yasuhiro ; Muraki, Chikara ; Tsuchiya, Kunihiko ; Matsuda, Kohei ; Ohiro, Yoichi ; Totsuka, Yasunori ; Shindoh, Masanobu
著者名 Ohga, Noritaka
e-Rad_Researcher 40399952 著者名 Hida, Kyoko
著者名 Hida, Yasuhiro
著者名 Muraki, Chikara
著者名 Tsuchiya, Kunihiko
著者名 Matsuda, Kohei
著者名 Ohiro, Yoichi
著者名 Totsuka, Yasunori
著者名 Shindoh, Masanobu
言語	英語
発行日	2009-10
出版者	Wiley-Blackwell
収録物名	Cancer Science
巻(号)	100(10)
ページ	1963-1970
抄録	The polyphenol epigallocatechin-3 gallate (EGCG) in green tea suppresses tumor growth by direct action on tumor cells and by inhibition of angiogenesis, but it is not known whether it specifically inhibits tumor angiogenesis. We examined the anti-angiogenic effect of EGCG on tumor-associated endothelial cells (TECs), endothelial progenitor cells (EPCs), and normal endothelial cells (NECs). EGCG suppressed the migration of TECs and EPCs but not NECs. EGCG also inhibited the phosphorylation of Akt in TECs but not in NECs. Furthermore, vascular endothelial growth factor-induced mobilization of EPCs into circulation was inhibited by EGCG. Matrix metalloproteinase-9 (MMP-9) in the bone marrow plasma plays key roles in EPC mobilization into circulation. We observed that expression of MMP-9 mRNA was downregulated by EGCG in mouse bone marrow stromal cells. In vivo model, EGCG suppressed growth of melanoma and reduced microvessel density. Our study showed that EGCG has selective anti-angiogenic effects on TECs and EPC. It is suggested that EGCG could be a promising angiogenesis inhibitor for cancer therapy.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The definitive version is available at www.blackwell-synergy.com
PISSN	1347-9032
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/j.1349-7006.2009.01255.x