The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through

Kiura, Kazuto; Kataoka, Hideo; Nakata, Takashi et al.

FEMS immunology and medical microbiology, 2006, 46(1), 78-84

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アクセス権
open access
URI
https://hdl.handle.net/2115/43979
タイトル
The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through
著者
Kiura, Kazuto ; Kataoka, Hideo ; Nakata, Takashi ; Into, Takeshi ; Yasuda, Motoaki ; Akira, Shizuo ; Inoue, Nobuo ; Shibata, Ken-ichiro
著者名
Kiura, Kazuto
著者名
Kataoka, Hideo
著者名
Nakata, Takashi
著者名
Into, Takeshi
著者名
Yasuda, Motoaki
著者名
Akira, Shizuo
著者名
Inoue, Nobuo
e-Rad_Researcher
50145265
著者名
Shibata, Ken-ichiro
言語
英語
キーワード
Dendritic cells
Toll-like receptor 2,
lipopeptide
ipopolysaccharide
発行日
2006-02
出版者
Blackwell
収録物名
FEMS immunology and medical microbiology
巻(号)
46(1)
ページ
78-84
抄録
GM-CSF-differentiated bone marrow-derived DCs (BMDCs) were stimulated with FSL-1 or E.coli LPS. FSL-1 induced the production of TNF-α and IL-12 by C57BL/6-derived BMDCs but not by BMDCs from Toll-like receptor 2-deficient (TLR2-/-) mice, whereas LPS induced the production of TNF-α and IL-12 by BMDCs derived from either type of mice. FSL-1 did not induce production of IL-10 by BMDCs from either type of mice, whereas LPS induced small amounts of IL-10 by BMDCs from both types of mice. FSL-1 upregulated the expression of CD80, CD86 and the MHC class II molecule IAb in both dose- and time-dependent manners on the surfaces of C57BL/6-derived BMDCs but not on the surface of TLR2-/--derived BMDCs, whereas LPS upregulated the expression of them on the surfaces of BMDCs from both types of mice. The expression of CD11c on the surfaces of C57BL/6-derived BMDCs was upregulated by stimulation with both FSL-1 and LPS up to 12 h and then the expression was downregulated.The results suggest that FSL-1 has activity to accelerate maturation of BMDCs and that the activity of FSL-1 is mediated by TLR2.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0928-8244
EISSN
1574-695X
NCID
AA10879949
関連情報
PMID
16420600
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1111/j.1574-695X.2005.00002.x