Strong adhesion of Saos-2 cells to multi-walled carbon nanotubes

Matsuoka, Makoto; Akasaka, Tsukasa; Totsuka, Yasunori; Watari, Fumio

Strong adhesion of Saos-2 cells to multi-walled carbon nanotubes

Matsuoka, Makoto; Akasaka, Tsukasa; Totsuka, Yasunori et al.

Materials Science and Engineering B, 2010, 173(1-3), 182-186

Permalink : https://hdl.handle.net/2115/44027

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アクセス権	open access
URI	https://hdl.handle.net/2115/44027
タイトル	Strong adhesion of Saos-2 cells to multi-walled carbon nanotubes
著者	Matsuoka, Makoto ; Akasaka, Tsukasa ; Totsuka, Yasunori ; Watari, Fumio
著者名 Matsuoka, Makoto
著者名 Akasaka, Tsukasa
著者名 Totsuka, Yasunori
著者名 Watari, Fumio
言語	英語
キーワード	Carbon nanotubes
	Osteoblast
	Adhesion
	Vinculin
発行日	2010-10-15
出版者	Elsevier B.V.
収録物名	Materials Science and Engineering B
巻(号)	173(1-3)
ページ	182-186
抄録	In recent years, carbon nanotubes (CNTs) have been considered potential biomedical materials because of their unique character. The aim of this study was to investigate the response of a human osteoblast-like cell line - Saos-2 - on single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs). The surface of a culture dish was coated with CNTs, and Saos-2 cells were cultured for three days. Cell morphology, viability, alkaline phosphatase (ALP) activity, adhesion, and vinculin expression were evaluated. The result showed high cell viability and strong adhesion to MWCNTs. Saos-2 cultured on MWCNTs exhibited vinculin expression throughout the cell body. while the cells attached to SWCNTs and glass were mostly limited to their periphery. Our results suggest that CNT coatings promote cell activity and adhesiveness. These findings indicate that MWCNTs could be used as surface coating materials to promote cell adhesion.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0921-5107
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.mseb.2009.12.044