DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc

Kim, Yun Chul; Kitaura, Hirotake; Iguchi-Ariga, Sanae M. M. et al.

FEBS Letters, 2010, 584(18), 3891-3895

Permalink : https://hdl.handle.net/2115/44034

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アクセス権	open access
URI	https://hdl.handle.net/2115/44034
タイトル	DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc
著者	Kim, Yun Chul ; Kitaura, Hirotake ; Iguchi-Ariga, Sanae M. M. ; Ariga, Hiroyoshi
著者名 Kim, Yun Chul
e-Rad_Researcher 10281817 著者名 Kitaura, Hirotake
著者名 Iguchi-Ariga, Sanae M. M.
著者名 Ariga, Hiroyoshi
言語	英語
キーワード	Simian virus 40
	DJ-1
	Transformation
	p53
発行日	2010-09-24
出版者	Elsevier B.V.
収録物名	FEBS Letters
巻(号)	584(18)
ページ	3891-3895
抄録	Simian virus 40 (SV40) is a tumor virus and its early gene product large T-antigen (LT) is responsible for the transforming activity of SV40. Parkinson's disease causative gene DJ-1 is also a ras-dependent oncogene, but the mechanism of its oncogene function is still not known. In this study, we found that there were no transformed foci when fibroblasts from DJ-1-knockout mice were transfected with LT. We also found that DJ-1 directly bound to LT and that the expression level of c-Myc in transformed cells was parallel to that of DJ-1. These findings indicate that DJ-1 is essential for SV40 transformation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0014-5793
関連情報	PMID 20708612
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.febslet.2010.08.010