Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis

Hattori, Takeshi; Konno, Satoshi; Takahashi, Ayumu; Isada, Akira; Shimizu, Kaoruko; Shimizu, Kenichi; Taniguchi, Natsuko; Gao, Peisong; Yamaguchi, Etsuro; Hizawa, Nobuyuki; Huang, Shau-Ku; Nishimura, Masaharu

Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis

Hattori, Takeshi; Konno, Satoshi; Takahashi, Ayumu et al.

BMC Medical Genetics, 2010, 11, 151

Permalink : https://hdl.handle.net/2115/44388

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アクセス権	open access
URI	https://hdl.handle.net/2115/44388
タイトル	Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
著者	Hattori, Takeshi ; Konno, Satoshi ; Takahashi, Ayumu ; Isada, Akira ; Shimizu, Kaoruko ; Shimizu, Kenichi ; Taniguchi, Natsuko ; Gao, Peisong ; Yamaguchi, Etsuro ; Hizawa, Nobuyuki ; Huang, Shau-Ku ; Nishimura, Masaharu
著者名 Hattori, Takeshi
著者名 Konno, Satoshi
著者名 Takahashi, Ayumu
著者名 Isada, Akira
著者名 Shimizu, Kaoruko
著者名 Shimizu, Kenichi
著者名 Taniguchi, Natsuko
著者名 Gao, Peisong
著者名 Yamaguchi, Etsuro
著者名 Hizawa, Nobuyuki
著者名 Huang, Shau-Ku
著者名 Nishimura, Masaharu
言語	英語
発行日	2010-10-28
出版者	BioMed Central
収録物名	BMC Medical Genetics
巻(号)	11
ページ	151
抄録	Background: Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis. Methods: Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 healthy controls. Results: Suggestive evidence of association between rs691005 SNP and risk of sarcoidosis was observed independent of sex and age in a recessive model (P = 0.001). Conclusions: These results suggest that MRC1 is an important candidate gene for sarcoidosis. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 2.0 Generic
PISSN	1471-2350
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/1471-2350-11-151